Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor

Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GIST derive from mutations in tyrosine kinase receptors (KIT) or platelet-derived growth factor receptor-α (PDGFRA). GISTs are rarely associated with par...

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Bibliographic Details
Main Authors: Maurizio Alletto, Antonio Burgio, Giovanni Fulco, Giulio Geraci, Concetta Groppuso, Gianfranco Gruttadauria, Elvio Manfrè, Gianluca Mastrosimone, Susanna Salvaggio, Giovanni Urrico, Federico Vancheri
Format: Article
Language:English
Published: PAGEPress Publications 2020-05-01
Series:Italian Journal of Medicine
Subjects:
Paraneoplastic hypoglycemia
gastrointestinal stromal tumour
non-islet cell tumor hypoglycemia
insulin-like growth factor.
Online Access:https://www.italjmed.org/index.php/ijm/article/view/1276
Description
Summary:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GIST derive from mutations in tyrosine kinase receptors (KIT) or platelet-derived growth factor receptor-α (PDGFRA). GISTs are rarely associated with paraneoplastic hypoglycemia caused by non-β-cells tumor. This syndrome, defined non-islet cell tumor hypoglycemia (NICTH), arises from excess tumor production of insulin-like growth factor. We describe a 67-year-old female with severe NICTH secondary to an advanced and metastatic GIST.
ISSN:1877-9344
1877-9352

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