Peroxisome proliferator-activated receptor-α activation facilitates contextual fear extinction and modulates intrinsic excitability of dentate gyrus neurons

Peroxisome proliferator-activated receptor-α activation facilitates contextual fear extinction and modulates intrinsic excitability of dentate gyrus neurons

Abstract The dentate gyrus (DG) of the hippocampus encodes contextual information associated with fear, and cell activity in the DG is required for acquisition and extinction of contextual fear. However, the underlying molecular mechanisms are not fully understood. Here we show that mice deficient f...

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Bibliographic Details
Main Authors: Guo Xiang, Xia Liu, Jiangong Wang, Shunshun Lu, Meng Yu, Yuhan Zhang, Bin Sun, Bin Huang, Xin-Yun Lu, Xingang Li, Di Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02496-1

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