Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats

Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats

Although progress has been achieved in the pharmacological activity and toxicity of Radix Polygoni Multiflori (RPM), the chemical basis of its toxicity is still unclear. Here, we performed a multicompound pharmacokinetic analysis and investigated the tissue distribution and excretion characteristics...

Full description

Bibliographic Details
Main Authors:	Wenhao Cheng, Siyang Wu, Zheng Yuan, Weiyu Hu, Xin Yu, Nianxin Kang, Qiutao Wang, Mingying Zhu, Kexin Xia, Wei Yang, Chen Kang, Shuofeng Zhang, Yingfei Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-02-01
Series:	Frontiers in Pharmacology
Subjects:	Radix Polygoni Multiflori pharmacokinetics tissue distribution excretion UPLC-MS/MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.827668/full

Similar Items

Integrating Targeted and Untargeted Metabolomics to Investigate the Processing Chemistry of Polygoni Multiflori Radix
by: Li Liang, et al.
Published: (2018-08-01)

Screening and identifying hepatotoxic components in Polygoni multiflori radix and Polygoni multiflori radix praeparata
by: Guang-Ping Zhang, et al.
Published: (2019-01-01)

Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis
by: Li Kang, et al.
Published: (2022-05-01)

Hepatotoxic metabolites in Polygoni Multiflori Radix— Comparative toxicology in mice
by: Shixiao Wang, et al.
Published: (2022-10-01)

Discrimination of Radix Polygoni Multiflori from different geographical areas by UPLC-QTOF/MS combined with chemometrics
by: Jin-Fa Tang, et al.
Published: (2017-12-01)

Comparative Investigation of Raw and Processed Radix Polygoni Multiflori on the Treatment of Vascular Dementia by Liquid Chromatograph−Mass Spectrometry Based Metabolomic Approach
by: Fengye Wu, et al.
Published: (2022-12-01)

On-line identification of the chemical constituents of Polygoni Multiflori Radix by UHPLC-Q-ToF MS/MS
by: Xueting Wang, et al.
Published: (2023-04-01)

Anti-aging activity of Radix polygoni multiflori preparata in aging mice model induced by D-galactose by bioassay method
by: Jiang Yan Huo, et al.
Published: (2016-03-01)

Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori
by: Dan Li, et al.
Published: (2020-11-01)

Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
by: Li Liang, et al.
Published: (2018-05-01)

Quality evaluation of various commercial specifications of Polygoni Multiflori Radix and its dregs by determination of active compounds
by: Liang Zhitao, et al.
Published: (2012-06-01)

Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata
by: Dan Gao, et al.
Published: (2016-10-01)

High-Throughput Identification of Organic Compounds from Polygoni Multiflori Radix Praeparata (<i>Zhiheshouwu</i>) by UHPLC-Q-Exactive Orbitrap-MS
by: Shaoyun Wang, et al.
Published: (2021-06-01)

Simultaneous Determination of Four Anthraquinones in Polygoni Multiflori Radix with Single Reference Standard by High Performance Liquid Chromatography
by: Hua Yang, et al.
Published: (2015-07-01)

Detection of Emodin Derived Glutathione Adduct in Normal Rats Administered with Large Dosage of Polygoni Multiflori Radix
by: Li-Long Jiang, et al.
Published: (2017-07-01)

Polygoni multiflori radix exacerbates idiosyncratic inflammatory liver injury through the FXR-SHP pathway and altered pharmacokinetic behavior
by: Guoqin Zhang, et al.
Published: (2023-04-01)

Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins
by: Funan Ning, et al.
Published: (2021-07-01)

Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis
by: Yihang Dai, et al.
Published: (2023-03-01)

Analyze the Effect of Steaming on the Chemical Constituents, Defecation and Liver Injury of Polygonum Multiflorum Radix (Heshouwu) by Multiple Analysis Techniques Combined with Multivariate Statistics
by: Xiaolei Du, et al.
Published: (2022-09-01)

Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury
by: Wei-Song Kong, et al.
Published: (2022-04-01)

<i>Caulis Polygoni Multiflori</i> Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways
by: Xin Yang, et al.
Published: (2022-09-01)

Polygoni Cuspidati Rhizoma et Radix extract attenuates high-fat diet-induced NAFLD in rats: Impact on untargeted serum metabolomics and liver lipidomics
by: Huan Zhang, et al.
Published: (2023-12-01)

Illumination on “Reserving Phloem and Discarding Xylem” and Quality Evaluation of Radix polygalae by Determining Oligosaccharide Esters, Saponins, and Xanthones
by: Fan Yang, et al.
Published: (2018-04-01)

Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness
by: Xintong Hu, et al.
Published: (2020-02-01)

Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches
by: Zha Xiaoyu, et al.
Published: (2022-08-01)

Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats
by: Wandi Du, et al.
Published: (2023-10-01)

Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis
by: Jing Chen, et al.
Published: (2023-05-01)

A Sensitive and Rapid UPLC-MS/MS Method for Determination of Monosaccharides and Anti-Allergic Effect of the Polysaccharides Extracted from Saposhnikoviae Radix
by: Yan-Yan Gao, et al.
Published: (2018-08-01)

Simultaneous quantification and evaluate the differences of two skeleton components in raw, salt and wine Angelicae Pubescentis Radix by UPLC-MS/MS in negative/positive modes coupled with chemometrics
by: Lin Yang, et al.
Published: (2022-03-01)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging
by: Hung-Yun Lin, et al.
Published: (2022-08-01)

Instability Mechanism of Osimertinib in Plasma and a Solving Strategy in the Pharmacokinetics Study
by: Zheng Yuan, et al.
Published: (2022-07-01)

Distribution Assessments of Coumarins from Angelicae Pubescentis Radix in Rat Cerebrospinal Fluid and Brain by Liquid Chromatography Tandem Mass Spectrometry Analysis
by: Yan-Fang Yang, et al.
Published: (2018-01-01)

The Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Pinostrobin in Rats: Ultra-High-Performance Liquid Chromatography Coupled With Linear Trap Quadrupole Orbitrap Mass Spectrometry Studies
by: Xiaoya Sun, et al.
Published: (2020-11-01)

Comprehensive evaluation of chemical constituents and antioxidant activity between crude and processed Polygalae radix based on UPLC-Q-TOF-MS/MS combined with multivariate statistical analysis
by: Yao Luo, et al.
Published: (2024-03-01)

The mechanism of action of paeoniae radix rubra–angelicae sinensis radix drug pair in the treatment of rheumatoid arthritis through PI3K/AKT/NF-κB signaling pathway
by: Jia Li, et al.
Published: (2023-03-01)

Metabolomic strategies and biochemical analysis of the effect of processed Rehmanniae radix extract on a blood-deficient rat model
by: Yang-yang Wang, et al.
Published: (2022-03-01)

Rapid characterization of chemical constituents in Radix Tetrastigma, a functional herbal mixture, before and after metabolism and their antioxidant/antiproliferative activities
by: Yong Sun, et al.
Published: (2015-10-01)

Deciphering the Differential Effective and Toxic Responses of Bupleuri Radix following the Induction of Chronic Unpredictable Mild Stress and in Healthy Rats Based on Serum Metabolic Profiles
by: Xiaoxia Gao, et al.
Published: (2018-01-01)

Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of Radix Inulae Extract
by: Renjie Xu, et al.
Published: (2015-04-01)

Integrating metabolic profile and network pharmacology to explore the chemical essence of Radix Ginseng Rubra for attenuating heart failure
by: Yinjie Wang, et al.
Published: (2024-01-01)