Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens
This comprehensive review delves into the complex interplay between mitochondrial gene defects and pancreatic cancer pathogenesis through a multiomics approach. By amalgamating data from genomic, transcriptomic, proteomic, and metabolomic studies, we dissected the mechanisms by which mitochondrial g...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375143/full |
| _version_ | 1797271695820587008 |
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| author | Hao Chi Hao Chi Lanqian Su Yalan Yan Xiang Gu Ke Su Han Li Lili Yu Jie Liu Jue Wang Qibiao Wu Guanhu Yang Guanhu Yang |
| author_facet | Hao Chi Hao Chi Lanqian Su Yalan Yan Xiang Gu Ke Su Han Li Lili Yu Jie Liu Jue Wang Qibiao Wu Guanhu Yang Guanhu Yang |
| author_sort | Hao Chi |
| collection | DOAJ |
| description | This comprehensive review delves into the complex interplay between mitochondrial gene defects and pancreatic cancer pathogenesis through a multiomics approach. By amalgamating data from genomic, transcriptomic, proteomic, and metabolomic studies, we dissected the mechanisms by which mitochondrial genetic variations dictate cancer progression. Emphasis has been placed on the roles of these genes in altering cellular metabolic processes, signal transduction pathways, and immune system interactions. We further explored how these findings could refine therapeutic interventions, with a particular focus on precision medicine applications. This analysis not only fills pivotal knowledge gaps about mitochondrial anomalies in pancreatic cancer but also paves the way for future investigations into personalized therapy options. This finding underscores the crucial nexus between mitochondrial genetics and oncological immunology, opening new avenues for targeted cancer treatment strategies. |
| first_indexed | 2024-03-07T14:11:07Z |
| format | Article |
| id | doaj.art-d1a7bd4db29a478a944195269d415f35 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T14:11:07Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d1a7bd4db29a478a944195269d415f352024-03-06T16:38:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13751431375143Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lensHao Chi0Hao Chi1Lanqian Su2Yalan Yan3Xiang Gu4Ke Su5Han Li6Lili Yu7Jie Liu8Jue Wang9Qibiao Wu10Guanhu Yang11Guanhu Yang12Faculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macau, Macao SAR, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaBiology Department, Southern Methodist University, Dallas, TX, United StatesDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaFaculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macau, Macao SAR, ChinaDepartment of General Surgery, Dazhou Central Hospital, Dazhou, ChinaFaculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macau, Macao SAR, ChinaFaculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macau, Macao SAR, ChinaFaculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macau, Macao SAR, ChinaDepartment of Specialty Medicine, Ohio University, Athens, OH, United StatesThis comprehensive review delves into the complex interplay between mitochondrial gene defects and pancreatic cancer pathogenesis through a multiomics approach. By amalgamating data from genomic, transcriptomic, proteomic, and metabolomic studies, we dissected the mechanisms by which mitochondrial genetic variations dictate cancer progression. Emphasis has been placed on the roles of these genes in altering cellular metabolic processes, signal transduction pathways, and immune system interactions. We further explored how these findings could refine therapeutic interventions, with a particular focus on precision medicine applications. This analysis not only fills pivotal knowledge gaps about mitochondrial anomalies in pancreatic cancer but also paves the way for future investigations into personalized therapy options. This finding underscores the crucial nexus between mitochondrial genetics and oncological immunology, opening new avenues for targeted cancer treatment strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375143/fullmitochondrial gene defectspancreatic cancermultiomics analysisimmune escapedisease progressionclinical application prospects |
| spellingShingle | Hao Chi Hao Chi Lanqian Su Yalan Yan Xiang Gu Ke Su Han Li Lili Yu Jie Liu Jue Wang Qibiao Wu Guanhu Yang Guanhu Yang Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens Frontiers in Immunology mitochondrial gene defects pancreatic cancer multiomics analysis immune escape disease progression clinical application prospects |
| title | Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens |
| title_full | Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens |
| title_fullStr | Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens |
| title_full_unstemmed | Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens |
| title_short | Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens |
| title_sort | illuminating the immunological landscape mitochondrial gene defects in pancreatic cancer through a multiomics lens |
| topic | mitochondrial gene defects pancreatic cancer multiomics analysis immune escape disease progression clinical application prospects |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375143/full |
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