ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising...

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Bibliographic Details
Main Authors: Daniel Wells, Emmanuelle Bitoun, Daniela Moralli, Gang Zhang, Anjali Hinch, Julia Jankowska, Peter Donnelly, Catherine Green, Simon R Myers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
meiosis
recombination
double strand break repair
ZCWPW1
PRDM9
DMC1
Online Access:https://elifesciences.org/articles/53392

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