Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia
BackgroundAbdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish the WC cut-off points to predict major cardiovascula...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1204885/full |
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| author | Jose P. Lopez-Lopez Jose P. Lopez-Lopez Ana María Gonzalez Paola Lanza Daniel Martinez-Bello Diego Gomez-Arbelaez Johanna Otero Daniel D. Cohen Maritza Perez-Mayorga Maritza Perez-Mayorga Angel A. Garcia-Peña Sumathy Rangarajan Salim Yusuf Patricio Lopez-Jaramillo |
| author_facet | Jose P. Lopez-Lopez Jose P. Lopez-Lopez Ana María Gonzalez Paola Lanza Daniel Martinez-Bello Diego Gomez-Arbelaez Johanna Otero Daniel D. Cohen Maritza Perez-Mayorga Maritza Perez-Mayorga Angel A. Garcia-Peña Sumathy Rangarajan Salim Yusuf Patricio Lopez-Jaramillo |
| author_sort | Jose P. Lopez-Lopez |
| collection | DOAJ |
| description | BackgroundAbdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish the WC cut-off points to predict major cardiovascular events (MACE) and incident diabetes.MethodsWe analyzed data from the cohort PURE study in Colombia. WC cut-off points were defined according to the maximum Youden index. Multivariate logistic regression was used to obtain associations between WC and MACE, diabetes, and cumulative incidence of outcomes visualized using Kaplan-Meier curves.ResultsAfter a mean follow-up of 12 years, 6,580 individuals with a mean age of 50.7 ± 9.7 years were included; 64.2% were women, and 53.5% were from rural areas. The mean WC was 85.2 ± 11.6 cm and 88.3 ± 11.1 cm in women and men, respectively. There were 635 cases of the MACE composite plus incident diabetes (5.25 events per 1,000 person-years). Using a cut-off value of 88.85 cm in men (sensitivity = 0.565) and 85.65 cm in women (sensitivity = 0.558) resulted in the highest value for the prediction of the main outcome. These values were associated with a 1.76 and 1.41-fold increased risk of presenting the composite outcome in men and women, respectively.ConclusionsWe defined WC cut-off points of 89 cm in men and 86 cm in women to identify the elevated risk of MACE and incident diabetes. Therefore, we suggest using these values in cardiovascular risk assessment in Latin America. |
| first_indexed | 2024-03-11T14:46:39Z |
| format | Article |
| id | doaj.art-d1a917827e514f338a9a09f3e77fc355 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-11T14:46:39Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-d1a917827e514f338a9a09f3e77fc3552023-10-30T11:12:14ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-10-011010.3389/fcvm.2023.12048851204885Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study ColombiaJose P. Lopez-Lopez0Jose P. Lopez-Lopez1Ana María Gonzalez2Paola Lanza3Daniel Martinez-Bello4Diego Gomez-Arbelaez5Johanna Otero6Daniel D. Cohen7Maritza Perez-Mayorga8Maritza Perez-Mayorga9Angel A. Garcia-Peña10Sumathy Rangarajan11Salim Yusuf12Patricio Lopez-Jaramillo13MASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaCardiology Unit, Department of Internal Medicine, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, ColombiaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaMedicine School, Universidad Militar Nueva Granada, Clínica Marly, Bogotá, ColombiaCardiology Unit, Department of Internal Medicine, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, ColombiaDepartment of Health Research Methods, Evidence, and Impact, McMaster University and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, CanadaDepartment of Health Research Methods, Evidence, and Impact, McMaster University and Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, CanadaMASIRA Research Institute, Universidad de Santander (UDES), Bucaramanga, ColombiaBackgroundAbdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish the WC cut-off points to predict major cardiovascular events (MACE) and incident diabetes.MethodsWe analyzed data from the cohort PURE study in Colombia. WC cut-off points were defined according to the maximum Youden index. Multivariate logistic regression was used to obtain associations between WC and MACE, diabetes, and cumulative incidence of outcomes visualized using Kaplan-Meier curves.ResultsAfter a mean follow-up of 12 years, 6,580 individuals with a mean age of 50.7 ± 9.7 years were included; 64.2% were women, and 53.5% were from rural areas. The mean WC was 85.2 ± 11.6 cm and 88.3 ± 11.1 cm in women and men, respectively. There were 635 cases of the MACE composite plus incident diabetes (5.25 events per 1,000 person-years). Using a cut-off value of 88.85 cm in men (sensitivity = 0.565) and 85.65 cm in women (sensitivity = 0.558) resulted in the highest value for the prediction of the main outcome. These values were associated with a 1.76 and 1.41-fold increased risk of presenting the composite outcome in men and women, respectively.ConclusionsWe defined WC cut-off points of 89 cm in men and 86 cm in women to identify the elevated risk of MACE and incident diabetes. Therefore, we suggest using these values in cardiovascular risk assessment in Latin America.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1204885/fullabdominal obesitywaist circumferencemajor cardiovascular eventsdiabetesLatin America |
| spellingShingle | Jose P. Lopez-Lopez Jose P. Lopez-Lopez Ana María Gonzalez Paola Lanza Daniel Martinez-Bello Diego Gomez-Arbelaez Johanna Otero Daniel D. Cohen Maritza Perez-Mayorga Maritza Perez-Mayorga Angel A. Garcia-Peña Sumathy Rangarajan Salim Yusuf Patricio Lopez-Jaramillo Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia Frontiers in Cardiovascular Medicine abdominal obesity waist circumference major cardiovascular events diabetes Latin America |
| title | Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia |
| title_full | Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia |
| title_fullStr | Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia |
| title_full_unstemmed | Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia |
| title_short | Waist circumference cut-off points to identify major cardiovascular events and incident diabetes in Latin America: findings from the prospective Urban rural epidemiology study Colombia |
| title_sort | waist circumference cut off points to identify major cardiovascular events and incident diabetes in latin america findings from the prospective urban rural epidemiology study colombia |
| topic | abdominal obesity waist circumference major cardiovascular events diabetes Latin America |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1204885/full |
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