Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging
Small animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/20/10/2793 |
| _version_ | 1797568055991074816 |
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| author | Kalloor Joseph Francis Richell Booijink Ruchi Bansal Wiendelt Steenbergen |
| author_facet | Kalloor Joseph Francis Richell Booijink Ruchi Bansal Wiendelt Steenbergen |
| author_sort | Kalloor Joseph Francis |
| collection | DOAJ |
| description | Small animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal imaging. However, the conventional photoacoustic tomographic systems use pulsed lasers, making it expensive, bulky, and require long acquisition time. In this work, we propose the use of photoacoustic and ultrasound tomographic imaging with LEDs as the light source and acoustic detection using a linear transducer array. We have demonstrated full-view tomographic imaging of a euthanized mouse and a potential application in liver fibrosis research. |
| first_indexed | 2024-03-10T19:50:57Z |
| format | Article |
| id | doaj.art-d1a9d2fcd8574b62a2ed5e060d89df2b |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T19:50:57Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-d1a9d2fcd8574b62a2ed5e060d89df2b2023-11-20T00:26:45ZengMDPI AGSensors1424-82202020-05-012010279310.3390/s20102793Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical ImagingKalloor Joseph Francis0Richell Booijink1Ruchi Bansal2Wiendelt Steenbergen3Biomedical Photonics Imaging (BMPI), Technical Medical Center, University of Twente, 7522 NH Enschede, The NetherlandsTranslational Liver Research, Medical Cell BioPhysics (MCBP), Technical Medical Center, University of Twente, 7522 NH Enschede, The NetherlandsTranslational Liver Research, Medical Cell BioPhysics (MCBP), Technical Medical Center, University of Twente, 7522 NH Enschede, The NetherlandsBiomedical Photonics Imaging (BMPI), Technical Medical Center, University of Twente, 7522 NH Enschede, The NetherlandsSmall animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal imaging. However, the conventional photoacoustic tomographic systems use pulsed lasers, making it expensive, bulky, and require long acquisition time. In this work, we propose the use of photoacoustic and ultrasound tomographic imaging with LEDs as the light source and acoustic detection using a linear transducer array. We have demonstrated full-view tomographic imaging of a euthanized mouse and a potential application in liver fibrosis research.https://www.mdpi.com/1424-8220/20/10/2793tomographyphotoacousticultrasoundsmall animalliverfibrosis |
| spellingShingle | Kalloor Joseph Francis Richell Booijink Ruchi Bansal Wiendelt Steenbergen Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging Sensors tomography photoacoustic ultrasound small animal liver fibrosis |
| title | Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging |
| title_full | Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging |
| title_fullStr | Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging |
| title_full_unstemmed | Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging |
| title_short | Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging |
| title_sort | tomographic ultrasound and led based photoacoustic system for preclinical imaging |
| topic | tomography photoacoustic ultrasound small animal liver fibrosis |
| url | https://www.mdpi.com/1424-8220/20/10/2793 |
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