A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery
CD45, the leukocyte common antigen, is expressed on almost all cells of the immunological and hematological systems. CD45 expression is related to a variety of diseases, including leukemia and lymphoma. In this study, we analyzed the expression level of CD45 across cancers and evaluated the relation...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.928328/full |
| _version_ | 1828425022376509440 |
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| author | Ni Ye Jie Cai Yulong Dong Huiyao Chen Zhiyuan Bo Xiaogang Zhao Mingyang Xia Mei Han |
| author_facet | Ni Ye Jie Cai Yulong Dong Huiyao Chen Zhiyuan Bo Xiaogang Zhao Mingyang Xia Mei Han |
| author_sort | Ni Ye |
| collection | DOAJ |
| description | CD45, the leukocyte common antigen, is expressed on almost all cells of the immunological and hematological systems. CD45 expression is related to a variety of diseases, including leukemia and lymphoma. In this study, we analyzed the expression level of CD45 across cancers and evaluated the relationship between its expression and patient prognosis. We further integrated methylation data to explore the differences in CD45 across cancers from a multi-omics perspective. We also analyzed the relationship between CD45 expression and levels of immune cell infiltrates and immune modifiers. Our results revealed the distinct expression characteristics and prognostic value of CD45 across multiple tumors. In addition, we screened drug targets based on the immune index defined by CD45 expression and identified that GPR84 affected the proliferation of tumor cells and was associated with the inflammation caused by immunotherapy. In summary, our findings provide a comprehensive understanding of the role of CD45 in oncogenesis and its prognostic significance across cancers. |
| first_indexed | 2024-12-10T16:25:17Z |
| format | Article |
| id | doaj.art-d1aa93df085541cf998d031e53591a7e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T16:25:17Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-d1aa93df085541cf998d031e53591a7e2022-12-22T01:41:41ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.928328928328A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discoveryNi Ye0Jie Cai1Yulong Dong2Huiyao Chen3Zhiyuan Bo4Xiaogang Zhao5Mingyang Xia6Mei Han7Department of General Practice, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaThe Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, ChinaMolecular Medical Center, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, ChinaKey Laboratory of Birth Defects, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of General Practice, The First Affiliated Hospital of Soochow University, Suzhou, ChinaCD45, the leukocyte common antigen, is expressed on almost all cells of the immunological and hematological systems. CD45 expression is related to a variety of diseases, including leukemia and lymphoma. In this study, we analyzed the expression level of CD45 across cancers and evaluated the relationship between its expression and patient prognosis. We further integrated methylation data to explore the differences in CD45 across cancers from a multi-omics perspective. We also analyzed the relationship between CD45 expression and levels of immune cell infiltrates and immune modifiers. Our results revealed the distinct expression characteristics and prognostic value of CD45 across multiple tumors. In addition, we screened drug targets based on the immune index defined by CD45 expression and identified that GPR84 affected the proliferation of tumor cells and was associated with the inflammation caused by immunotherapy. In summary, our findings provide a comprehensive understanding of the role of CD45 in oncogenesis and its prognostic significance across cancers.https://www.frontiersin.org/articles/10.3389/fgene.2022.928328/fullCD45cancer immunotherapytumor microenvironmentbiomarkerprognosispancancer |
| spellingShingle | Ni Ye Jie Cai Yulong Dong Huiyao Chen Zhiyuan Bo Xiaogang Zhao Mingyang Xia Mei Han A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery Frontiers in Genetics CD45 cancer immunotherapy tumor microenvironment biomarker prognosis pancancer |
| title | A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery |
| title_full | A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery |
| title_fullStr | A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery |
| title_full_unstemmed | A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery |
| title_short | A multi-omic approach reveals utility of CD45 expression in prognosis and novel target discovery |
| title_sort | multi omic approach reveals utility of cd45 expression in prognosis and novel target discovery |
| topic | CD45 cancer immunotherapy tumor microenvironment biomarker prognosis pancancer |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.928328/full |
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