The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study)
Abstract Background Osteoarthritis (OA) represents a leading cause of disability with limited data available for the Greek patients. Objectives To evaluate the impact of moderate to severe symptomatic hip/knee OA under treatment on physical performance and quality of life. Methods A non-intervention...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-023-06770-7 |
| _version_ | 1797454179319414784 |
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| author | P. Savvari I. Skiadas S. A. Papadakis V. Psychogios O. D. Argyropoulou A. P. Pastroudis G. A. Skarpas A. Tsoutsanis A. Garofalakis G. Katsifis D. Boumpas D. Menegas |
| author_facet | P. Savvari I. Skiadas S. A. Papadakis V. Psychogios O. D. Argyropoulou A. P. Pastroudis G. A. Skarpas A. Tsoutsanis A. Garofalakis G. Katsifis D. Boumpas D. Menegas |
| author_sort | P. Savvari |
| collection | DOAJ |
| description | Abstract Background Osteoarthritis (OA) represents a leading cause of disability with limited data available for the Greek patients. Objectives To evaluate the impact of moderate to severe symptomatic hip/knee OA under treatment on physical performance and quality of life. Methods A non-interventional, cross-sectional, epidemiological study of patients with moderate/severe OA, recruited in a single visit from 9 expert sites in Athens, Greece. Assessments were based on commonly used outcome scales: the Hip disability and Osteoarthritis Outcome Score (HOOS), the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the EuroQol-5-Dimensions 3-levels questionnaire (EQ-5D-3L). Results One hundred sixty-four patients were included in the analysis. Most of the patients were females (78.7%), with a mean age of 70.5 ± 10.2 years. Comorbidities were reported by 87.2% of patients with hypertension being the most frequently reported (53.7%), followed by dyslipidemia (31.1%), obesity (24.4%) and diabetes mellitus (23.2%). Paracetamol was the most common treatment (96%), followed by NSAIDs (75%), opioids (50%) and locally applied medications (42.7%). Both hip and knee OA patients showed substantial deterioration in health-related quality of life (QoL) and health status as reflected by the HOOS/KOOS (Function in sport and recreation was the most impaired subscale, followed by Hip- or Knee-related QoL). The mean EQ-5D-3L index score was 0.396 ± 0.319 and the mean EQ-VAS score was 52.1 ± 1.9. When compared indirectly to the local population norms our OA population had worse QoL indices. Conclusion Our findings suggest the functional disability and impaired QoL of Greek patients with moderate/severe hip/knee OA under treatment emphasizing the need for novel treatments that will reduce the burden of the disease. |
| first_indexed | 2024-03-09T15:33:32Z |
| format | Article |
| id | doaj.art-d1ab2741b86b4b46bd43d5bcb9b902ee |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-03-09T15:33:32Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-d1ab2741b86b4b46bd43d5bcb9b902ee2023-11-26T12:07:32ZengBMCBMC Musculoskeletal Disorders1471-24742023-08-0124111110.1186/s12891-023-06770-7The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study)P. Savvari0I. Skiadas1S. A. Papadakis2V. Psychogios3O. D. Argyropoulou4A. P. Pastroudis5G. A. Skarpas6A. Tsoutsanis7A. Garofalakis8G. Katsifis9D. Boumpas10D. Menegas11Internal Medicine Department Pfizer Hellas, Neo PsychikoInternal Medicine Department Pfizer Hellas, Neo Psychiko2nd Orthopedic Department, KAT General Hospital of Attica5th Orthopedic Department, Asclepeion General HospitalDepartment of Pathophysiology, National and Kapodistrian University of Athens6th Orthopedic Department, Asclepeion General Hospital3rd Orthopedic Department for Sports Injuries and Regenerative Medicine, Mitera General Hospital6th Orthopedic Department Hygeia Hospital1st Orthopedic Department, Mitera General HospitalRheumatology Department, Naval Hospital Athens4th Internal Medicine Department, Attikon University HospitalInternal Medicine Department Pfizer Hellas, Neo PsychikoAbstract Background Osteoarthritis (OA) represents a leading cause of disability with limited data available for the Greek patients. Objectives To evaluate the impact of moderate to severe symptomatic hip/knee OA under treatment on physical performance and quality of life. Methods A non-interventional, cross-sectional, epidemiological study of patients with moderate/severe OA, recruited in a single visit from 9 expert sites in Athens, Greece. Assessments were based on commonly used outcome scales: the Hip disability and Osteoarthritis Outcome Score (HOOS), the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the EuroQol-5-Dimensions 3-levels questionnaire (EQ-5D-3L). Results One hundred sixty-four patients were included in the analysis. Most of the patients were females (78.7%), with a mean age of 70.5 ± 10.2 years. Comorbidities were reported by 87.2% of patients with hypertension being the most frequently reported (53.7%), followed by dyslipidemia (31.1%), obesity (24.4%) and diabetes mellitus (23.2%). Paracetamol was the most common treatment (96%), followed by NSAIDs (75%), opioids (50%) and locally applied medications (42.7%). Both hip and knee OA patients showed substantial deterioration in health-related quality of life (QoL) and health status as reflected by the HOOS/KOOS (Function in sport and recreation was the most impaired subscale, followed by Hip- or Knee-related QoL). The mean EQ-5D-3L index score was 0.396 ± 0.319 and the mean EQ-VAS score was 52.1 ± 1.9. When compared indirectly to the local population norms our OA population had worse QoL indices. Conclusion Our findings suggest the functional disability and impaired QoL of Greek patients with moderate/severe hip/knee OA under treatment emphasizing the need for novel treatments that will reduce the burden of the disease.https://doi.org/10.1186/s12891-023-06770-7Hip osteoarthritisKnee osteoarthritisHealth Related Quality of Life (HRQoL)Joint diseasesMusculoskeletal diseases |
| spellingShingle | P. Savvari I. Skiadas S. A. Papadakis V. Psychogios O. D. Argyropoulou A. P. Pastroudis G. A. Skarpas A. Tsoutsanis A. Garofalakis G. Katsifis D. Boumpas D. Menegas The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study) BMC Musculoskeletal Disorders Hip osteoarthritis Knee osteoarthritis Health Related Quality of Life (HRQoL) Joint diseases Musculoskeletal diseases |
| title | The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study) |
| title_full | The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study) |
| title_fullStr | The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study) |
| title_full_unstemmed | The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study) |
| title_short | The impact of moderate to severe osteoarthritis on the physical performance and quality of life: a cross-sectional study in Greek patients (PONOS study) |
| title_sort | impact of moderate to severe osteoarthritis on the physical performance and quality of life a cross sectional study in greek patients ponos study |
| topic | Hip osteoarthritis Knee osteoarthritis Health Related Quality of Life (HRQoL) Joint diseases Musculoskeletal diseases |
| url | https://doi.org/10.1186/s12891-023-06770-7 |
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