The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells

The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells

Abstract Background We have previously shown that the zinc finger transcription repressor SNAI2 (SLUG) represses tumor suppressor BRCA2-expression in non-dividing cells by binding to the E2-box upstream of the transcription start site. However, it is unclear how proliferating breast cancer (BC) cell...

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Bibliographic Details
Main Authors: Marshall Ellison, Mukul Mittal, Minu Chaudhuri, Gautam Chaudhuri, Smita Misra
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
BRCA2
PRDX5A
SLUG
miR6855-3p
Redox
Online Access:https://doi.org/10.1186/s12964-019-0493-5

Internet

https://doi.org/10.1186/s12964-019-0493-5

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