SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II), COBALT(III) AND IRON(III) COORDINATION COMPOUNDS WITH 1-(2-HYDROXYPHENYL)ETHANONE N(4)-ALLYL-S-METHYLISOTHIOSEMICARBAZONE
<p>The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this pro-ligand. The newly obtained compounds were investigated by IR, <sup>1</sup>H and <...
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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Moldova State University
2018-11-01
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| Σειρά: | Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
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| Διαθέσιμο Online: | http://ojs.studiamsu.eu/index.php/real-nature/article/view/1112 |
| Περίληψη: | <p>The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this pro-ligand. The newly obtained compounds were investigated by IR, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. For the synthesized compounds the antibacterial and antifungal activities <em>in vitro</em> were studied on a series of standard strains, such as <em>Staphylococcus aureus</em> (ATCC 25923), <em>Escherihia coli</em> (ATCC 25922), <em>Klebsiella pneumonae</em> and <em>Candida albicans</em>. The <em>in vitro</em> antiproliferative activity of the pro-ligand and complexes was screened on Hep-2, BxPC-3, RD cancer cells and normal MDCK cells. It was established that coordination compounds manifest better antiproliferative activity than the pro-ligand.</p><p><strong>SINTEZA, CARACTERIZAREA ȘI ACTIVITATEA BIOLOGICĂ A COMPUŞILORCOORDINATIVI AI CUPRULUI(II), NICHELULUI(II), COBALTULUI(III) ŞI AI FIERULUI(III) CU N(4)-ALIL-S-METILIZOTIOSEMICARBAZONA 1-(2-HIDROXIFENIL)ETANONEI</strong></p><p>În lucrare este descrisă sinteza N(4)-alil-S-metilizotiosemicarbazonei 1-(2-hidroxifenil)etanonei (HL) şi a şapte compuşi coordinativi ai cuprului, nichelului, cobaltului şi ai fierului cu acest ligand. Compușii noi obținuți au fost studiați cu ajutorul spectroscopiilor IR şi RMN (<sup>1</sup>H şi <sup>13</sup>C), analizei elementale, conductivitaţii molare şi susceptibilității magnetice. Pentru compușii sintetizați a fost studiată <em>in vitro</em> activitatea antibacterială şi antifungică selectivă faţa de spectrul larg de tulpini standard de <em>Staphylococcus</em><em> aureus</em> (ATCC 25923), <em>Escherihia</em><em> coli</em> (ATCC 25922), <em>Klebsiella pneumonae</em> şi <em>Candida albicans.</em> Cercetarea proprităţilor antiproliferative <em>in vitro</em> ale ligandului și ale complecșilor a fost testată pe celule canceroase Hep-2, BxPC-3, RD și celule normale MDCK.<em> </em>S-a stabilit că compuşii coordinativi manifestă o activitate mai bună decât ligandul.</p> |
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| ISSN: | 1814-3237 1857-498X |