Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge.
Although acute stressors are known for stimulating the production of glucocorticoids and pro-inflammatory cytokines in rodents, the effects of chronic stressors on cytokine levels and the activation of the hypothalamic-pituitary-adrenal (HPA) axis, especially in response to a subsequent challenge, a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0297776 |
| _version_ | 1797295171850731520 |
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| author | Mariella Bodemeier Loayza Careaga T John Wu |
| author_facet | Mariella Bodemeier Loayza Careaga T John Wu |
| author_sort | Mariella Bodemeier Loayza Careaga |
| collection | DOAJ |
| description | Although acute stressors are known for stimulating the production of glucocorticoids and pro-inflammatory cytokines in rodents, the effects of chronic stressors on cytokine levels and the activation of the hypothalamic-pituitary-adrenal (HPA) axis, especially in response to a subsequent challenge, are less clear. In this study, male and female mice were exposed to 6 weeks of chronic variable stress (CVS) and the peripheral and central levels of IL-1β, IL-6, and TNF-α, as well as the HPA axis reactivity, were measured after an acute injection of LPS. The findings indicate that the pro-inflammatory profile in the plasma, regardless of stress exposure, was similar between male and female animals, whereas there was a region-, sex-, and stress-dependent pattern in the brain. Exposure to chronic stressors blunted the HPA reactivity to the LPS challenge, indicating a modulatory effect on the stress axis responsiveness. |
| first_indexed | 2024-03-07T21:42:55Z |
| format | Article |
| id | doaj.art-d1ad0b5d6a974c33a40be436cb304a15 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-07T21:42:55Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d1ad0b5d6a974c33a40be436cb304a152024-02-26T05:31:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029777610.1371/journal.pone.0297776Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge.Mariella Bodemeier Loayza CareagaT John WuAlthough acute stressors are known for stimulating the production of glucocorticoids and pro-inflammatory cytokines in rodents, the effects of chronic stressors on cytokine levels and the activation of the hypothalamic-pituitary-adrenal (HPA) axis, especially in response to a subsequent challenge, are less clear. In this study, male and female mice were exposed to 6 weeks of chronic variable stress (CVS) and the peripheral and central levels of IL-1β, IL-6, and TNF-α, as well as the HPA axis reactivity, were measured after an acute injection of LPS. The findings indicate that the pro-inflammatory profile in the plasma, regardless of stress exposure, was similar between male and female animals, whereas there was a region-, sex-, and stress-dependent pattern in the brain. Exposure to chronic stressors blunted the HPA reactivity to the LPS challenge, indicating a modulatory effect on the stress axis responsiveness.https://doi.org/10.1371/journal.pone.0297776 |
| spellingShingle | Mariella Bodemeier Loayza Careaga T John Wu Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge. PLoS ONE |
| title | Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge. |
| title_full | Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge. |
| title_fullStr | Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge. |
| title_full_unstemmed | Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge. |
| title_short | Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge. |
| title_sort | chronically stressed male and female mice show a similar peripheral and central pro inflammatory profile after an immune challenge |
| url | https://doi.org/10.1371/journal.pone.0297776 |
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