Adrenergic receptor β3 is involved in the memory consolidation process in mice
Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharm...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2018-08-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000607&lng=en&tlng=en |
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| author | P. Souza-Braga F.B. Lorena B.P.P. Nascimento C.P. Marcelino T.T. Ravache E. Ricci M.M. Bernardi M.O. Ribeiro |
| author_facet | P. Souza-Braga F.B. Lorena B.P.P. Nascimento C.P. Marcelino T.T. Ravache E. Ricci M.M. Bernardi M.O. Ribeiro |
| author_sort | P. Souza-Braga |
| collection | DOAJ |
| description | Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends on the action of both the β3 (β3-AR) and β2 (β2-AR) receptor subtypes. However, the use of animal models with specific knockout for the β3-AR receptor only (β3-ARKO) allows researchers to more accurately assess its role in memory formation processes. In the present study, we evaluated short- and long-term memory acquisition capacity in β3-ARKO mice and wild-type mice at approximately 60 days of age. The animals were submitted to the open field test, the elevated plus maze, object recognition, and social preference. The results showed that the absence of the β3-AR receptor caused no impairment in locomotion and did not cause anxious behavior, but it caused significant impairment of short- and long-term memory compared to wild-type animals. We also evaluated the expression of genes involved in memory consolidation. The mRNA levels for GLUT3, a glucose transporter expressed in the central nervous system, were significantly reduced in the amygdala, but not in the hippocampus of the β3-ARKO animals. Our results showed that β3-AR was involved in the process of acquisition of declarative memory, and its action may be due to the facilitation of glucose absorption in the amygdala. |
| first_indexed | 2024-04-12T08:00:11Z |
| format | Article |
| id | doaj.art-d1af345661b74f29a35eb8628e872558 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-12T08:00:11Z |
| publishDate | 2018-08-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-d1af345661b74f29a35eb8628e8725582022-12-22T03:41:20ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2018-08-01511010.1590/1414-431x20187564S0100-879X2018001000607Adrenergic receptor β3 is involved in the memory consolidation process in miceP. Souza-BragaF.B. LorenaB.P.P. NascimentoC.P. MarcelinoT.T. RavacheE. RicciM.M. BernardiM.O. RibeiroAttention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends on the action of both the β3 (β3-AR) and β2 (β2-AR) receptor subtypes. However, the use of animal models with specific knockout for the β3-AR receptor only (β3-ARKO) allows researchers to more accurately assess its role in memory formation processes. In the present study, we evaluated short- and long-term memory acquisition capacity in β3-ARKO mice and wild-type mice at approximately 60 days of age. The animals were submitted to the open field test, the elevated plus maze, object recognition, and social preference. The results showed that the absence of the β3-AR receptor caused no impairment in locomotion and did not cause anxious behavior, but it caused significant impairment of short- and long-term memory compared to wild-type animals. We also evaluated the expression of genes involved in memory consolidation. The mRNA levels for GLUT3, a glucose transporter expressed in the central nervous system, were significantly reduced in the amygdala, but not in the hippocampus of the β3-ARKO animals. Our results showed that β3-AR was involved in the process of acquisition of declarative memory, and its action may be due to the facilitation of glucose absorption in the amygdala.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000607&lng=en&tlng=enAdrenergic receptorsMemoryGLUT3β3-AR |
| spellingShingle | P. Souza-Braga F.B. Lorena B.P.P. Nascimento C.P. Marcelino T.T. Ravache E. Ricci M.M. Bernardi M.O. Ribeiro Adrenergic receptor β3 is involved in the memory consolidation process in mice Brazilian Journal of Medical and Biological Research Adrenergic receptors Memory GLUT3 β3-AR |
| title | Adrenergic receptor β3 is involved in the memory consolidation process in mice |
| title_full | Adrenergic receptor β3 is involved in the memory consolidation process in mice |
| title_fullStr | Adrenergic receptor β3 is involved in the memory consolidation process in mice |
| title_full_unstemmed | Adrenergic receptor β3 is involved in the memory consolidation process in mice |
| title_short | Adrenergic receptor β3 is involved in the memory consolidation process in mice |
| title_sort | adrenergic receptor β3 is involved in the memory consolidation process in mice |
| topic | Adrenergic receptors Memory GLUT3 β3-AR |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000607&lng=en&tlng=en |
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