Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile
Hydrogels are promising materials for various applications, including drug delivery, tissue engineering, and wastewater treatment. In this work, we designed an alginate (ALG) hydrogel containing partially deacetylated chitin nanowhiskers (CNW) as a filler. Gelation in the system occurred by both the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/9/7/291 |
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| author | Valentina A. Petrova Vladimir Y. Elokhovskiy Sergei V. Raik Daria N. Poshina Dmitry P. Romanov Yury A. Skorik |
| author_facet | Valentina A. Petrova Vladimir Y. Elokhovskiy Sergei V. Raik Daria N. Poshina Dmitry P. Romanov Yury A. Skorik |
| author_sort | Valentina A. Petrova |
| collection | DOAJ |
| description | Hydrogels are promising materials for various applications, including drug delivery, tissue engineering, and wastewater treatment. In this work, we designed an alginate (ALG) hydrogel containing partially deacetylated chitin nanowhiskers (CNW) as a filler. Gelation in the system occurred by both the protonation of alginic acid and the formation of a polyelectrolyte complex with deacetylated CNW surface chains. Morphological changes in the gel manifested as a honeycomb structure in the freeze-dried gel, unlike the layered structure of an ALG gel. Disturbance of the structural orientation of the gels by the introduction of CNW was also expressed as a decrease in the intensity of X-ray diffraction reflexes. All studied systems were non-Newtonian liquids that violated the Cox-Merz rule. An increase in the content of CNW in the ALG-CNW hydrogel resulted in increases in the yield stress, maximum Newtonian viscosity, and relaxation time. Inclusion of CNW prolonged the release of tetracycline due to changes in diffusion. The first phases (0−5 h) of the release profiles were well described by the Higuchi model. ALG-CNW hydrogels may be of interest as soft gels for controlled topical or intestinal drug delivery. |
| first_indexed | 2024-04-13T21:26:22Z |
| format | Article |
| id | doaj.art-d1b041a5538141b583ca4247670024f0 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-04-13T21:26:22Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d1b041a5538141b583ca4247670024f02022-12-22T02:29:18ZengMDPI AGBiomolecules2218-273X2019-07-019729110.3390/biom9070291biom9070291Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release ProfileValentina A. Petrova0Vladimir Y. Elokhovskiy1Sergei V. Raik2Daria N. Poshina3Dmitry P. Romanov4Yury A. Skorik5Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, St Petersburg 199004, RussiaInstitute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, St Petersburg 199004, RussiaInstitute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, St Petersburg 199004, RussiaInstitute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, St Petersburg 199004, RussiaInstitute of Silicate Chemistry of the Russian Academy of Sciences, Adm. Makarova emb. 2, St. Petersburg 199034, RussiaInstitute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, St Petersburg 199004, RussiaHydrogels are promising materials for various applications, including drug delivery, tissue engineering, and wastewater treatment. In this work, we designed an alginate (ALG) hydrogel containing partially deacetylated chitin nanowhiskers (CNW) as a filler. Gelation in the system occurred by both the protonation of alginic acid and the formation of a polyelectrolyte complex with deacetylated CNW surface chains. Morphological changes in the gel manifested as a honeycomb structure in the freeze-dried gel, unlike the layered structure of an ALG gel. Disturbance of the structural orientation of the gels by the introduction of CNW was also expressed as a decrease in the intensity of X-ray diffraction reflexes. All studied systems were non-Newtonian liquids that violated the Cox-Merz rule. An increase in the content of CNW in the ALG-CNW hydrogel resulted in increases in the yield stress, maximum Newtonian viscosity, and relaxation time. Inclusion of CNW prolonged the release of tetracycline due to changes in diffusion. The first phases (0−5 h) of the release profiles were well described by the Higuchi model. ALG-CNW hydrogels may be of interest as soft gels for controlled topical or intestinal drug delivery.https://www.mdpi.com/2218-273X/9/7/291alginic acidchitinhydrogeltetracyclinedrug delivery |
| spellingShingle | Valentina A. Petrova Vladimir Y. Elokhovskiy Sergei V. Raik Daria N. Poshina Dmitry P. Romanov Yury A. Skorik Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile Biomolecules alginic acid chitin hydrogel tetracycline drug delivery |
| title | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
| title_full | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
| title_fullStr | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
| title_full_unstemmed | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
| title_short | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
| title_sort | alginate gel reinforcement with chitin nanowhiskers modulates rheological properties and drug release profile |
| topic | alginic acid chitin hydrogel tetracycline drug delivery |
| url | https://www.mdpi.com/2218-273X/9/7/291 |
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