Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover

Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover

Endoplasmic reticulum (ER) oxidoreductin 1α (Ero1α) is a disulfide producer in the ER of mammalian cells. Besides four catalytic cysteines (Cys94, Cys99, Cys394, Cys397), Ero1α harbors four regulatory cysteines (Cys104, Cys131, Cys208, Cys241). These cysteines mediate the formation of inhibitory int...

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Bibliographic Details
Main Authors: Thomas Ramming, Shingo Kanemura, Masaki Okumura, Kenji Inaba, Christian Appenzeller-Herzog
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Redox Biology
Subjects:
Ero1α
PDI
Disulfide bond
Redox homeostasis
Endoplasmic reticulum
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231715300057

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