Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults
It has been established that inflammation leads to a variety of changes in social experience, but one area of social experience that has been overlooked is subjective social status. Furthermore, given sex differences in the relationship between inflammation and social status, males may be more sensi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-10-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2019.02167/full |
| _version_ | 1819052507346763776 |
|---|---|
| author | Mona Moieni Mona Moieni Keely A. Muscatell Keely A. Muscatell Ivana Jevtic Elizabeth C. Breen Michael R. Irwin Naomi I. Eisenberger |
| author_facet | Mona Moieni Mona Moieni Keely A. Muscatell Keely A. Muscatell Ivana Jevtic Elizabeth C. Breen Michael R. Irwin Naomi I. Eisenberger |
| author_sort | Mona Moieni |
| collection | DOAJ |
| description | It has been established that inflammation leads to a variety of changes in social experience, but one area of social experience that has been overlooked is subjective social status. Furthermore, given sex differences in the relationship between inflammation and social status, males may be more sensitive to inflammation-induced changes in social status. However, no previous studies in humans have examined this possibility. In the present study, healthy young participants (n = 115) were randomly assigned to receive either endotoxin, an experimental inflammatory challenge, or placebo. Participants reported their subjective social status at baseline (prior to injection), and approximately 2 h later (time of peak inflammatory response for the endotoxin group). Results, using ANCOVA analyses, indicated that males exposed to endotoxin, but not females, reported lower levels of subjective social status at the peak of inflammatory response (vs. placebo). These results suggest that males may be more sensitive to the effects of inflammation in certain social domains, such as perceived social status.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT01671150. |
| first_indexed | 2024-12-21T12:20:56Z |
| format | Article |
| id | doaj.art-d1b3213af9804ded9812ddc291ced222 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-21T12:20:56Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-d1b3213af9804ded9812ddc291ced2222022-12-21T19:04:19ZengFrontiers Media S.A.Frontiers in Psychology1664-10782019-10-011010.3389/fpsyg.2019.02167486585Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young AdultsMona Moieni0Mona Moieni1Keely A. Muscatell2Keely A. Muscatell3Ivana Jevtic4Elizabeth C. Breen5Michael R. Irwin6Naomi I. Eisenberger7Department of Psychology, University of California, Los Angeles, Los Angeles, CA, United StatesCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesUNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United StatesCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, United StatesCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, United StatesIt has been established that inflammation leads to a variety of changes in social experience, but one area of social experience that has been overlooked is subjective social status. Furthermore, given sex differences in the relationship between inflammation and social status, males may be more sensitive to inflammation-induced changes in social status. However, no previous studies in humans have examined this possibility. In the present study, healthy young participants (n = 115) were randomly assigned to receive either endotoxin, an experimental inflammatory challenge, or placebo. Participants reported their subjective social status at baseline (prior to injection), and approximately 2 h later (time of peak inflammatory response for the endotoxin group). Results, using ANCOVA analyses, indicated that males exposed to endotoxin, but not females, reported lower levels of subjective social status at the peak of inflammatory response (vs. placebo). These results suggest that males may be more sensitive to the effects of inflammation in certain social domains, such as perceived social status.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT01671150.https://www.frontiersin.org/article/10.3389/fpsyg.2019.02167/fullinflammationsubjective social statussocial behaviorendotoxinsex |
| spellingShingle | Mona Moieni Mona Moieni Keely A. Muscatell Keely A. Muscatell Ivana Jevtic Elizabeth C. Breen Michael R. Irwin Naomi I. Eisenberger Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults Frontiers in Psychology inflammation subjective social status social behavior endotoxin sex |
| title | Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults |
| title_full | Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults |
| title_fullStr | Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults |
| title_full_unstemmed | Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults |
| title_short | Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults |
| title_sort | sex differences in the effect of inflammation on subjective social status a randomized controlled trial of endotoxin in healthy young adults |
| topic | inflammation subjective social status social behavior endotoxin sex |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2019.02167/full |
| work_keys_str_mv | AT monamoieni sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults AT monamoieni sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults AT keelyamuscatell sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults AT keelyamuscatell sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults AT ivanajevtic sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults AT elizabethcbreen sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults AT michaelrirwin sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults AT naomiieisenberger sexdifferencesintheeffectofinflammationonsubjectivesocialstatusarandomizedcontrolledtrialofendotoxininhealthyyoungadults |