The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy
The treatment outcome of breast cancer is closely related to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Triple-negative breast cancer (TNBC) lacking ER, PR, and HER2 expression has limited treatment options and a poor prognosis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194020/full |
| _version_ | 1797824128428802048 |
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| author | Ruonan Li Lili Cao Lili Cao |
| author_facet | Ruonan Li Lili Cao Lili Cao |
| author_sort | Ruonan Li |
| collection | DOAJ |
| description | The treatment outcome of breast cancer is closely related to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Triple-negative breast cancer (TNBC) lacking ER, PR, and HER2 expression has limited treatment options and a poor prognosis. Tumor-infiltrating lymphocytes (TILs) play a role in promoting or resisting tumors by affecting the tumor microenvironment and are known as key regulators in breast cancer progression. However, treatments for TNBC (e.g., surgery, chemotherapy and radiotherapy) have non-satisfaction’s curative effect so far. This article reviews the role of different types of TILs in TNBC and the research progress of adoptive cell therapy, aiming to provide new therapeutic approaches for TNBC. |
| first_indexed | 2024-03-13T10:34:24Z |
| format | Article |
| id | doaj.art-d1b6f74969864245a5a5375f61b32d2c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T10:34:24Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d1b6f74969864245a5a5375f61b32d2c2023-05-18T07:47:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11940201194020The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapyRuonan Li0Lili Cao1Lili Cao2Oncology Department, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaOncology Department, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine and Shandong Lung Cancer Institute, Jinan, ChinaThe treatment outcome of breast cancer is closely related to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Triple-negative breast cancer (TNBC) lacking ER, PR, and HER2 expression has limited treatment options and a poor prognosis. Tumor-infiltrating lymphocytes (TILs) play a role in promoting or resisting tumors by affecting the tumor microenvironment and are known as key regulators in breast cancer progression. However, treatments for TNBC (e.g., surgery, chemotherapy and radiotherapy) have non-satisfaction’s curative effect so far. This article reviews the role of different types of TILs in TNBC and the research progress of adoptive cell therapy, aiming to provide new therapeutic approaches for TNBC.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194020/fulltriple-negative breast cancer (TNBC)tumor-infiltrating lymphocytes (TILs)adoptive cell therapy (ACT)breast cancersolid tumor |
| spellingShingle | Ruonan Li Lili Cao Lili Cao The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy Frontiers in Immunology triple-negative breast cancer (TNBC) tumor-infiltrating lymphocytes (TILs) adoptive cell therapy (ACT) breast cancer solid tumor |
| title | The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy |
| title_full | The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy |
| title_fullStr | The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy |
| title_full_unstemmed | The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy |
| title_short | The role of tumor-infiltrating lymphocytes in triple-negative breast cancer and the research progress of adoptive cell therapy |
| title_sort | role of tumor infiltrating lymphocytes in triple negative breast cancer and the research progress of adoptive cell therapy |
| topic | triple-negative breast cancer (TNBC) tumor-infiltrating lymphocytes (TILs) adoptive cell therapy (ACT) breast cancer solid tumor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1194020/full |
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