A case of membranous nephropathy associated with relapsing polychondritis

Relapsing polychondritis (RP) is a rare, chronic, and potentially fatal multisystemic inflammatory disorder targeting cartilaginous structures. This disorder is frequently associated with rheumatoid arthritis, systemic vasculitis, connective tissue diseases, and hematologic disorders, but renal invo...

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Bibliographic Details
Main Authors: Ji-eun Lee, Eun Kyoung Lee
Format: Article
Language:English
Published: The Korean Society of Nephrology 2012-12-01
Series:Kidney Research and Clinical Practice
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211913212007474
Description
Summary:Relapsing polychondritis (RP) is a rare, chronic, and potentially fatal multisystemic inflammatory disorder targeting cartilaginous structures. This disorder is frequently associated with rheumatoid arthritis, systemic vasculitis, connective tissue diseases, and hematologic disorders, but renal involvement is unusual. In the literature, associated renal pathology includes mesangial expansion, IgA nephropathy, tubulointerstitial nephritis, and segmental necrotizing crescentic glomerulonephritis. We report a case of a 49-year-old male found to have RP and nephrotic syndrome, with confirmed membranous nephropathy on kidney biopsy. He responded well to corticosteroids and cyclosporine. This is the first case of renal associated RP confirmed by renal biopsy in Korea. Membranous nephropathy associated with RP has never before been reported.
ISSN:2211-9132