A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children
Purpose: This study aimed to evaluate whether vitamin D supplementation can reduce the incidence of influenza and enterovirus infection in Taiwanese children. Methods: This randomized, double-blind, controlled trial included children aged two to five years between April 2018 and October 2019 from da...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118222000196 |
| _version_ | 1811237170129666048 |
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| author | Ya-Ning Huang Hsin Chi Nan-Chang Chiu Ching-Ying Huang Sung-Tse Li Jin-Yuan Wang Daniel Tsung-Ning Huang |
| author_facet | Ya-Ning Huang Hsin Chi Nan-Chang Chiu Ching-Ying Huang Sung-Tse Li Jin-Yuan Wang Daniel Tsung-Ning Huang |
| author_sort | Ya-Ning Huang |
| collection | DOAJ |
| description | Purpose: This study aimed to evaluate whether vitamin D supplementation can reduce the incidence of influenza and enterovirus infection in Taiwanese children. Methods: This randomized, double-blind, controlled trial included children aged two to five years between April 2018 and October 2019 from daycare centers. All the participants were randomly assigned to a vitamin D supplementation group (2000 IU/day) or placebo group for one month. The primary outcome was the incidence of influenza and enterovirus infection in the following six months, and the secondary outcome was the incidence of influenza and enterovirus infection in the children's household members. Results: Two hundred and forty-eight children participated. The vitamin D group showed a relative risk reduction of 84% against influenza compared to the placebo group but did not reach statistical significance. Kaplan–Meier curves revealed that the placebo group had a higher probability of influenza infection than the vitamin D group (log-rank test, p = 0.055), but the incidence of enterovirus infection was similar between the two groups (p = 0.946) among children. Among children's household members, the incidence of influenza (p = 0.586) and enterovirus infection (p = 0.528) were both similar between the two groups. All children who were tested for serum 25(OH)D levels after vitamin D intervention had 25(OH)D levels above 30 ng/ml Conclusion: Vitamin D supplementation may have a small preventative effect against influenza infection but does not affect enterovirus infection among preschool children. A high-dose short-term vitamin D intervention might be a way to elevate children's serum vitamin D levels in the first month of starting kindergarten. |
| first_indexed | 2024-04-12T12:21:31Z |
| format | Article |
| id | doaj.art-d1ba970c78794d1f93fa9f2271c202b3 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-12T12:21:31Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-d1ba970c78794d1f93fa9f2271c202b32022-12-22T03:33:18ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822022-10-01555803811A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in childrenYa-Ning Huang0Hsin Chi1Nan-Chang Chiu2Ching-Ying Huang3Sung-Tse Li4Jin-Yuan Wang5Daniel Tsung-Ning Huang6Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu, TaiwanDepartment of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medicine College, New Taipei, TaiwanDepartment of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medicine College, New Taipei, TaiwanDepartment of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medicine College, New Taipei, TaiwanDepartment of Medicine, MacKay Medicine College, New Taipei, Taiwan; Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan; Department of Healthcare Management, Yuanpei University of Medical Technology, Hsinchu, TaiwanDepartment of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, TaiwanDepartment of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medicine College, New Taipei, Taiwan; Corresponding author. Department of Pediatric Infectious Diseases, MacKay Children's Hospital, Taipei, Taiwan.Purpose: This study aimed to evaluate whether vitamin D supplementation can reduce the incidence of influenza and enterovirus infection in Taiwanese children. Methods: This randomized, double-blind, controlled trial included children aged two to five years between April 2018 and October 2019 from daycare centers. All the participants were randomly assigned to a vitamin D supplementation group (2000 IU/day) or placebo group for one month. The primary outcome was the incidence of influenza and enterovirus infection in the following six months, and the secondary outcome was the incidence of influenza and enterovirus infection in the children's household members. Results: Two hundred and forty-eight children participated. The vitamin D group showed a relative risk reduction of 84% against influenza compared to the placebo group but did not reach statistical significance. Kaplan–Meier curves revealed that the placebo group had a higher probability of influenza infection than the vitamin D group (log-rank test, p = 0.055), but the incidence of enterovirus infection was similar between the two groups (p = 0.946) among children. Among children's household members, the incidence of influenza (p = 0.586) and enterovirus infection (p = 0.528) were both similar between the two groups. All children who were tested for serum 25(OH)D levels after vitamin D intervention had 25(OH)D levels above 30 ng/ml Conclusion: Vitamin D supplementation may have a small preventative effect against influenza infection but does not affect enterovirus infection among preschool children. A high-dose short-term vitamin D intervention might be a way to elevate children's serum vitamin D levels in the first month of starting kindergarten.http://www.sciencedirect.com/science/article/pii/S1684118222000196Vitamin D supplementationSeasonal InfluenzaInfluenza infectionEnterovirus infection |
| spellingShingle | Ya-Ning Huang Hsin Chi Nan-Chang Chiu Ching-Ying Huang Sung-Tse Li Jin-Yuan Wang Daniel Tsung-Ning Huang A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children Journal of Microbiology, Immunology and Infection Vitamin D supplementation Seasonal Influenza Influenza infection Enterovirus infection |
| title | A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children |
| title_full | A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children |
| title_fullStr | A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children |
| title_full_unstemmed | A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children |
| title_short | A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children |
| title_sort | randomized trial of vitamin d supplementation to prevent seasonal influenza and enterovirus infection in children |
| topic | Vitamin D supplementation Seasonal Influenza Influenza infection Enterovirus infection |
| url | http://www.sciencedirect.com/science/article/pii/S1684118222000196 |
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