Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges
Immune associated cells in the microenvironment have a significant impact on the development and progression of hepatocellular carcinoma (HCC) and have received more and more attention. Different types of immune-associated cells play different roles, including promoting/inhibiting HCC and several di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.775462/full |
| _version_ | 1798033130081222656 |
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| author | Xiaopei Hao Guangshun Sun Yao Zhang Xiangyi Kong Dawei Rong Jinhua Song Weiwei Tang Xuehao Wang |
| author_facet | Xiaopei Hao Guangshun Sun Yao Zhang Xiangyi Kong Dawei Rong Jinhua Song Weiwei Tang Xuehao Wang |
| author_sort | Xiaopei Hao |
| collection | DOAJ |
| description | Immune associated cells in the microenvironment have a significant impact on the development and progression of hepatocellular carcinoma (HCC) and have received more and more attention. Different types of immune-associated cells play different roles, including promoting/inhibiting HCC and several different types that are controversial. It is well known that immune escape of HCC has become a difficult problem in tumor therapy. Therefore, in recent years, a large number of studies have focused on the immune microenvironment of HCC, explored many mechanisms worth identifying tumor immunosuppression, and developed a variety of immunotherapy methods as targets, laying the foundation for the final victory in the fight against HCC. This paper reviews recent studies on the immune microenvironment of HCC that are more reliable and important, and provides a more comprehensive view of the investigation of the immune microenvironment of HCC and the development of more immunotherapeutic approaches based on the relevant summaries of different immune cells. |
| first_indexed | 2024-04-11T20:25:11Z |
| format | Article |
| id | doaj.art-d1bafe28d3f044619713762a5ed6c6a3 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T20:25:11Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-d1bafe28d3f044619713762a5ed6c6a32022-12-22T04:04:42ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-11-01910.3389/fcell.2021.775462775462Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and ChallengesXiaopei Hao0Guangshun Sun1Yao Zhang2Xiangyi Kong3Dawei Rong4Jinhua Song5Weiwei Tang6Xuehao Wang7Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, ChinaDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, ChinaHepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing, ChinaImmune associated cells in the microenvironment have a significant impact on the development and progression of hepatocellular carcinoma (HCC) and have received more and more attention. Different types of immune-associated cells play different roles, including promoting/inhibiting HCC and several different types that are controversial. It is well known that immune escape of HCC has become a difficult problem in tumor therapy. Therefore, in recent years, a large number of studies have focused on the immune microenvironment of HCC, explored many mechanisms worth identifying tumor immunosuppression, and developed a variety of immunotherapy methods as targets, laying the foundation for the final victory in the fight against HCC. This paper reviews recent studies on the immune microenvironment of HCC that are more reliable and important, and provides a more comprehensive view of the investigation of the immune microenvironment of HCC and the development of more immunotherapeutic approaches based on the relevant summaries of different immune cells.https://www.frontiersin.org/articles/10.3389/fcell.2021.775462/fullHCCTAMNK cellcancer immunotherapychallengedevelopment |
| spellingShingle | Xiaopei Hao Guangshun Sun Yao Zhang Xiangyi Kong Dawei Rong Jinhua Song Weiwei Tang Xuehao Wang Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges Frontiers in Cell and Developmental Biology HCC TAM NK cell cancer immunotherapy challenge development |
| title | Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges |
| title_full | Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges |
| title_fullStr | Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges |
| title_full_unstemmed | Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges |
| title_short | Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges |
| title_sort | targeting immune cells in the tumor microenvironment of hcc new opportunities and challenges |
| topic | HCC TAM NK cell cancer immunotherapy challenge development |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.775462/full |
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