Association of lower plasma citric acid with prolonged cough: the Nagahama study
Abstract Little is known about the association of prolonged cough, a common and troublesome symptom, with metabolic pathways. We aimed to clarify this association using data from the Nagahama cohort, a prospective study of participants from the general population. Self-report questionnaires on prolo...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40878-z |
| _version_ | 1827711116532252672 |
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| author | Satoru Terada Hisako Matsumoto Kenta Nishi Mariko Kogo Natsuko Nomura Noriyuki Tashima Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuhiro Sonomura Fumihiko Matsuda Kazuo Chin Toyohiro Hirai |
| author_facet | Satoru Terada Hisako Matsumoto Kenta Nishi Mariko Kogo Natsuko Nomura Noriyuki Tashima Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuhiro Sonomura Fumihiko Matsuda Kazuo Chin Toyohiro Hirai |
| author_sort | Satoru Terada |
| collection | DOAJ |
| description | Abstract Little is known about the association of prolonged cough, a common and troublesome symptom, with metabolic pathways. We aimed to clarify this association using data from the Nagahama cohort, a prospective study of participants from the general population. Self-report questionnaires on prolonged cough were collected at baseline and 5-year follow-up assessments. Blood tests at follow-up were used for gas chromatography-mass spectrometry-based metabolomics. The association between metabolites and prolonged cough was examined using the partial least squares discriminant analysis and multiple regression analysis. Among the 7432 participants, 632 had newly developed prolonged cough at follow-up, which was defined as “new-onset prolonged cough”. Low plasma citric acid was significantly associated with new-onset prolonged cough, even after the adjustment of confounding factors including the presence of asthma, upper airway cough syndrome (UACS), and gastroesophageal reflux disease (GERD). A similar association was observed for isocitric acid, 3-hydroxybutyric acid, and 3-hydroxyisobutyric acid. The analysis of these four metabolites revealed that citric acid had the strongest association with new-onset prolonged cough. This significant association remained even when the analysis was confined to participants with UACS or GERD at baseline or follow-up, and these associations were also observed in participants (n = 976) who had prolonged cough at follow-up regardless of baseline status. In conclusion, low blood citric acid may be associated with prolonged cough. |
| first_indexed | 2024-03-10T17:50:16Z |
| format | Article |
| id | doaj.art-d1bd0f2937bb491ea83cee5acbcf050d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:50:16Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d1bd0f2937bb491ea83cee5acbcf050d2023-11-20T09:24:23ZengNature PortfolioScientific Reports2045-23222023-08-011311910.1038/s41598-023-40878-zAssociation of lower plasma citric acid with prolonged cough: the Nagahama studySatoru Terada0Hisako Matsumoto1Kenta Nishi2Mariko Kogo3Natsuko Nomura4Noriyuki Tashima5Chie Morimoto6Hironobu Sunadome7Tadao Nagasaki8Tsuyoshi Oguma9Yoshinari Nakatsuka10Kimihiko Murase11Takahisa Kawaguchi12Yasuharu Tabara13Kazuhiro Sonomura14Fumihiko Matsuda15Kazuo Chin16Toyohiro Hirai17Department of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineCenter for Genomic Medicine, Kyoto University Graduate School of MedicineCenter for Genomic Medicine, Kyoto University Graduate School of MedicineCenter for Genomic Medicine, Kyoto University Graduate School of MedicineCenter for Genomic Medicine, Kyoto University Graduate School of MedicineCenter for Genomic Medicine, Kyoto University Graduate School of MedicineDepartment of Respiratory Medicine, Kyoto University Graduate School of MedicineAbstract Little is known about the association of prolonged cough, a common and troublesome symptom, with metabolic pathways. We aimed to clarify this association using data from the Nagahama cohort, a prospective study of participants from the general population. Self-report questionnaires on prolonged cough were collected at baseline and 5-year follow-up assessments. Blood tests at follow-up were used for gas chromatography-mass spectrometry-based metabolomics. The association between metabolites and prolonged cough was examined using the partial least squares discriminant analysis and multiple regression analysis. Among the 7432 participants, 632 had newly developed prolonged cough at follow-up, which was defined as “new-onset prolonged cough”. Low plasma citric acid was significantly associated with new-onset prolonged cough, even after the adjustment of confounding factors including the presence of asthma, upper airway cough syndrome (UACS), and gastroesophageal reflux disease (GERD). A similar association was observed for isocitric acid, 3-hydroxybutyric acid, and 3-hydroxyisobutyric acid. The analysis of these four metabolites revealed that citric acid had the strongest association with new-onset prolonged cough. This significant association remained even when the analysis was confined to participants with UACS or GERD at baseline or follow-up, and these associations were also observed in participants (n = 976) who had prolonged cough at follow-up regardless of baseline status. In conclusion, low blood citric acid may be associated with prolonged cough.https://doi.org/10.1038/s41598-023-40878-z |
| spellingShingle | Satoru Terada Hisako Matsumoto Kenta Nishi Mariko Kogo Natsuko Nomura Noriyuki Tashima Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuhiro Sonomura Fumihiko Matsuda Kazuo Chin Toyohiro Hirai Association of lower plasma citric acid with prolonged cough: the Nagahama study Scientific Reports |
| title | Association of lower plasma citric acid with prolonged cough: the Nagahama study |
| title_full | Association of lower plasma citric acid with prolonged cough: the Nagahama study |
| title_fullStr | Association of lower plasma citric acid with prolonged cough: the Nagahama study |
| title_full_unstemmed | Association of lower plasma citric acid with prolonged cough: the Nagahama study |
| title_short | Association of lower plasma citric acid with prolonged cough: the Nagahama study |
| title_sort | association of lower plasma citric acid with prolonged cough the nagahama study |
| url | https://doi.org/10.1038/s41598-023-40878-z |
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