Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite
Chitosan is a cationic polymer that forms polymerized membranes upon reaction with anionic polymers. Chitosan−carboxymethyl cellulose (CMC) capsules are drug delivery carrier candidates whose mechanical strength and permeability must be controlled to achieve sustained release. In this study, the cap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/5/1111 |
| _version_ | 1797496536588877824 |
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| author | Yuki Shirosaki Yasuyo Tsukatani Kohei Okamoto Satoshi Hayakawa Akiyoshi Osaka |
| author_facet | Yuki Shirosaki Yasuyo Tsukatani Kohei Okamoto Satoshi Hayakawa Akiyoshi Osaka |
| author_sort | Yuki Shirosaki |
| collection | DOAJ |
| description | Chitosan is a cationic polymer that forms polymerized membranes upon reaction with anionic polymers. Chitosan−carboxymethyl cellulose (CMC) capsules are drug delivery carrier candidates whose mechanical strength and permeability must be controlled to achieve sustained release. In this study, the capsules were prepared from chitosan−γ-glycidoxypropyltrimethoxysilane (GPTMS)−CMC. The mechanical stability of the capsules was improved by crosslinking the chitosan with GPTMS. The capsules were then coated with hydroxyapatite (HAp) by alternately soaking them in calcium chloride solution and disodium hydrogen phosphate solution to prevent rapid initial drug release. Cytochrome C (CC), as a model drug, was introduced into the capsules via two routes, impregnation and injection, and then the CC released from the capsules was examined. HAp was found to be deposited on the internal and external surfaces of the capsules. The amount of CC introduced, and the release rate were reduced by the HAp coating. The injection method was found to result in the greatest CC loading. |
| first_indexed | 2024-03-10T03:06:03Z |
| format | Article |
| id | doaj.art-d1bdda42c59b4cb6b0cbaef4b9f0c58d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:06:03Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj.art-d1bdda42c59b4cb6b0cbaef4b9f0c58d2023-11-23T12:39:48ZengMDPI AGPharmaceutics1999-49232022-05-01145111110.3390/pharmaceutics14051111Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with HydroxyapatiteYuki Shirosaki0Yasuyo Tsukatani1Kohei Okamoto2Satoshi Hayakawa3Akiyoshi Osaka4Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensuicho, Tobata-ku, Kitakyushu 804-8550, JapanGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, JapanGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, JapanFaculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, JapanGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, JapanChitosan is a cationic polymer that forms polymerized membranes upon reaction with anionic polymers. Chitosan−carboxymethyl cellulose (CMC) capsules are drug delivery carrier candidates whose mechanical strength and permeability must be controlled to achieve sustained release. In this study, the capsules were prepared from chitosan−γ-glycidoxypropyltrimethoxysilane (GPTMS)−CMC. The mechanical stability of the capsules was improved by crosslinking the chitosan with GPTMS. The capsules were then coated with hydroxyapatite (HAp) by alternately soaking them in calcium chloride solution and disodium hydrogen phosphate solution to prevent rapid initial drug release. Cytochrome C (CC), as a model drug, was introduced into the capsules via two routes, impregnation and injection, and then the CC released from the capsules was examined. HAp was found to be deposited on the internal and external surfaces of the capsules. The amount of CC introduced, and the release rate were reduced by the HAp coating. The injection method was found to result in the greatest CC loading.https://www.mdpi.com/1999-4923/14/5/1111chitosan–siloxane hybridcapsulehydroxyapatite coatingdrug release |
| spellingShingle | Yuki Shirosaki Yasuyo Tsukatani Kohei Okamoto Satoshi Hayakawa Akiyoshi Osaka Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite Pharmaceutics chitosan–siloxane hybrid capsule hydroxyapatite coating drug release |
| title | Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite |
| title_full | Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite |
| title_fullStr | Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite |
| title_full_unstemmed | Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite |
| title_short | Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite |
| title_sort | preparation and drug release profile of chitosan siloxane hybrid capsules coated with hydroxyapatite |
| topic | chitosan–siloxane hybrid capsule hydroxyapatite coating drug release |
| url | https://www.mdpi.com/1999-4923/14/5/1111 |
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