Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients
Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is still poorly understood. We recorded local field potentials from...
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| Format: | Article |
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eLife Sciences Publications Ltd
2021-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/65444 |
| _version_ | 1811227808601473024 |
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| author | Yongzhi Huang Bomin Sun Jean Debarros Chao Zhang Shikun Zhan Dianyou Li Chencheng Zhang Tao Wang Peng Huang Yijie Lai Peter Brown Chunyan Cao Huiling Tan |
| author_facet | Yongzhi Huang Bomin Sun Jean Debarros Chao Zhang Shikun Zhan Dianyou Li Chencheng Zhang Tao Wang Peng Huang Yijie Lai Peter Brown Chunyan Cao Huiling Tan |
| author_sort | Yongzhi Huang |
| collection | DOAJ |
| description | Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is still poorly understood. We recorded local field potentials from bilateral habenula areas with simultaneous cortical magnetoencephalography in nine patients with psychiatric disorders during an emotional picture-viewing task. Transient activity in the theta/alpha band (5–10 Hz) within the habenula and prefrontal cortical regions, as well as the coupling between these structures, is increased during the perception and processing of negative emotional stimuli compared to positive emotional stimuli. The increase in theta/alpha band synchronization in the frontal cortex-habenula network correlated with the emotional valence but not the arousal score of the stimuli. These results provide direct evidence for increased theta/alpha synchrony within the habenula area and prefrontal cortex-habenula network in the perception of negative emotion in human participants. |
| first_indexed | 2024-04-12T09:46:59Z |
| format | Article |
| id | doaj.art-d1be7f195e9d467e9a06802e7e0d3844 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:46:59Z |
| publishDate | 2021-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d1be7f195e9d467e9a06802e7e0d38442022-12-22T03:37:55ZengeLife Sciences Publications LtdeLife2050-084X2021-07-011010.7554/eLife.65444Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patientsYongzhi Huang0https://orcid.org/0000-0002-2503-1589Bomin Sun1Jean Debarros2Chao Zhang3Shikun Zhan4Dianyou Li5Chencheng Zhang6Tao Wang7Peng Huang8Yijie Lai9Peter Brown10https://orcid.org/0000-0002-5201-3044Chunyan Cao11Huiling Tan12https://orcid.org/0000-0001-8038-3029Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United KingdomDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Research Council (MRC) Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Research Council (MRC) Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMedical Research Council (MRC) Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomLateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is still poorly understood. We recorded local field potentials from bilateral habenula areas with simultaneous cortical magnetoencephalography in nine patients with psychiatric disorders during an emotional picture-viewing task. Transient activity in the theta/alpha band (5–10 Hz) within the habenula and prefrontal cortical regions, as well as the coupling between these structures, is increased during the perception and processing of negative emotional stimuli compared to positive emotional stimuli. The increase in theta/alpha band synchronization in the frontal cortex-habenula network correlated with the emotional valence but not the arousal score of the stimuli. These results provide direct evidence for increased theta/alpha synchrony within the habenula area and prefrontal cortex-habenula network in the perception of negative emotion in human participants.https://elifesciences.org/articles/65444habenulaprefrontal cortex-habenula networkemotional stimulitheta / alpha oscillationsdeep brain stimulationdepression |
| spellingShingle | Yongzhi Huang Bomin Sun Jean Debarros Chao Zhang Shikun Zhan Dianyou Li Chencheng Zhang Tao Wang Peng Huang Yijie Lai Peter Brown Chunyan Cao Huiling Tan Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients eLife habenula prefrontal cortex-habenula network emotional stimuli theta / alpha oscillations deep brain stimulation depression |
| title | Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients |
| title_full | Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients |
| title_fullStr | Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients |
| title_full_unstemmed | Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients |
| title_short | Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients |
| title_sort | increased theta alpha synchrony in the habenula prefrontal network with negative emotional stimuli in human patients |
| topic | habenula prefrontal cortex-habenula network emotional stimuli theta / alpha oscillations deep brain stimulation depression |
| url | https://elifesciences.org/articles/65444 |
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