Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma
<i>Background and Objectives</i>: Patients with seminal vesicle invasion (SVI) are a highly heterogeneous group. Prognosis can be affected by many clinical and pathological characteristics. Our aim was to study whether bilateral SVI (bi-SVI) is associated with worse oncological outcomes....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/8/1057 |
| _version_ | 1797431986216763392 |
|---|---|
| author | Natalia Vidal Crespo Laura Enguita Arnal Álvaro Gómez-Ferrer Argimiro Collado Serra Juan Manuel Mascarós Ana Calatrava Fons Juan Casanova Ramón-Borja José Rubio Briones Miguel Ramírez-Backhaus |
| author_facet | Natalia Vidal Crespo Laura Enguita Arnal Álvaro Gómez-Ferrer Argimiro Collado Serra Juan Manuel Mascarós Ana Calatrava Fons Juan Casanova Ramón-Borja José Rubio Briones Miguel Ramírez-Backhaus |
| author_sort | Natalia Vidal Crespo |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Patients with seminal vesicle invasion (SVI) are a highly heterogeneous group. Prognosis can be affected by many clinical and pathological characteristics. Our aim was to study whether bilateral SVI (bi-SVI) is associated with worse oncological outcomes. <i>Materials and Methods</i>: This is an observational retrospective study that included 146 pT3b patients treated with radical prostatectomy (RP). We compared the results between unilateral SVI (uni-SVI) and bi-SVI. The log-rank test and Kaplan–Meier curves were used to compare biochemical recurrence-free survival (BCR), metastasis-free survival (MFS), and additional treatment-free survival. Cox proportional hazard models were used to identify predictors of BCR-free survival, MFS, and additional treatment-free survival. <i>Results</i>: 34.93% of patients had bi-SVI. The median follow-up was 46.84 months. No significant differences were seen between the uni-SVI and bi-SVI groups. BCR-free survival at 5 years was 33.31% and 25.65% (<i>p</i> = 0.44) for uni-SVI and bi-SVI. MFS at 5 years was 86.03% vs. 75.63% (<i>p</i> = 0.1), and additional treatment-free survival was 36.85% vs. 21.93% (<i>p</i> = 0.09), respectively. In the multivariate analysis, PSA was related to the development of BCR [HR 1.34 (95%CI: 1.01–1.77); <i>p</i> = 0.03] and metastasis [HR 1.83 (95%CI: 1.13–2.98); <i>p</i> = 0.02]. BCR was also influenced by lymph node infiltration [HR 2.74 (95%CI: 1.41–5.32); <i>p</i> = 0.003]. Additional treatment was performed more frequently in patients with positive margins [HR: 3.50 (95%CI: 1.65–7.44); <i>p</i> = 0.001]. <i>Conclusions</i>: SVI invasion is an adverse pathology feature, with a widely variable prognosis. In our study, bilateral seminal vesicle invasion did not predict worse outcomes in pT3b patients despite being associated with more undifferentiated tumors. |
| first_indexed | 2024-03-09T09:53:16Z |
| format | Article |
| id | doaj.art-d1be83e0f18942f9b75ffa99f5e019a4 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T09:53:16Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-d1be83e0f18942f9b75ffa99f5e019a42023-12-01T23:58:38ZengMDPI AGMedicina1010-660X1648-91442022-08-01588105710.3390/medicina58081057Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate CarcinomaNatalia Vidal Crespo0Laura Enguita Arnal1Álvaro Gómez-Ferrer2Argimiro Collado Serra3Juan Manuel Mascarós4Ana Calatrava Fons5Juan Casanova Ramón-Borja6José Rubio Briones7Miguel Ramírez-Backhaus8Department of Urology, Hospital General Universitario Santa Lucía, 30202 Cartagena, SpainDepartment of Urology, Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainDepartment of Urology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainDepartment of Urology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainDepartment of Urology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainDepartment of Pathology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainDepartment of Urology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainDepartment of Urology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainDepartment of Urology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain<i>Background and Objectives</i>: Patients with seminal vesicle invasion (SVI) are a highly heterogeneous group. Prognosis can be affected by many clinical and pathological characteristics. Our aim was to study whether bilateral SVI (bi-SVI) is associated with worse oncological outcomes. <i>Materials and Methods</i>: This is an observational retrospective study that included 146 pT3b patients treated with radical prostatectomy (RP). We compared the results between unilateral SVI (uni-SVI) and bi-SVI. The log-rank test and Kaplan–Meier curves were used to compare biochemical recurrence-free survival (BCR), metastasis-free survival (MFS), and additional treatment-free survival. Cox proportional hazard models were used to identify predictors of BCR-free survival, MFS, and additional treatment-free survival. <i>Results</i>: 34.93% of patients had bi-SVI. The median follow-up was 46.84 months. No significant differences were seen between the uni-SVI and bi-SVI groups. BCR-free survival at 5 years was 33.31% and 25.65% (<i>p</i> = 0.44) for uni-SVI and bi-SVI. MFS at 5 years was 86.03% vs. 75.63% (<i>p</i> = 0.1), and additional treatment-free survival was 36.85% vs. 21.93% (<i>p</i> = 0.09), respectively. In the multivariate analysis, PSA was related to the development of BCR [HR 1.34 (95%CI: 1.01–1.77); <i>p</i> = 0.03] and metastasis [HR 1.83 (95%CI: 1.13–2.98); <i>p</i> = 0.02]. BCR was also influenced by lymph node infiltration [HR 2.74 (95%CI: 1.41–5.32); <i>p</i> = 0.003]. Additional treatment was performed more frequently in patients with positive margins [HR: 3.50 (95%CI: 1.65–7.44); <i>p</i> = 0.001]. <i>Conclusions</i>: SVI invasion is an adverse pathology feature, with a widely variable prognosis. In our study, bilateral seminal vesicle invasion did not predict worse outcomes in pT3b patients despite being associated with more undifferentiated tumors.https://www.mdpi.com/1648-9144/58/8/1057prostate cancerseminal vesicle invasionradical prostatectomybiochemical recurrencesurvival |
| spellingShingle | Natalia Vidal Crespo Laura Enguita Arnal Álvaro Gómez-Ferrer Argimiro Collado Serra Juan Manuel Mascarós Ana Calatrava Fons Juan Casanova Ramón-Borja José Rubio Briones Miguel Ramírez-Backhaus Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma Medicina prostate cancer seminal vesicle invasion radical prostatectomy biochemical recurrence survival |
| title | Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma |
| title_full | Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma |
| title_fullStr | Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma |
| title_full_unstemmed | Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma |
| title_short | Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma |
| title_sort | bilateral seminal vesicle invasion is not associated with worse outcomes in locally advanced prostate carcinoma |
| topic | prostate cancer seminal vesicle invasion radical prostatectomy biochemical recurrence survival |
| url | https://www.mdpi.com/1648-9144/58/8/1057 |
| work_keys_str_mv | AT nataliavidalcrespo bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT lauraenguitaarnal bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT alvarogomezferrer bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT argimirocolladoserra bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT juanmanuelmascaros bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT anacalatravafons bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT juancasanovaramonborja bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT joserubiobriones bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma AT miguelramirezbackhaus bilateralseminalvesicleinvasionisnotassociatedwithworseoutcomesinlocallyadvancedprostatecarcinoma |