Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila
Food regulates taste perception, but the underlying molecular mechanisms are not clear. Here, the authors reveal that sugar intake in Drosophila induces the gut to secrete Hedgehog into the circulation that suppresses sweet taste, sugar perception and preference.
Main Authors: | Yunpo Zhao, Mohammed A. Khallaf, Emilia Johansson, Najat Dzaki, Shreelatha Bhat, Johannes Alfredsson, Jianli Duan, Bill S. Hansson, Markus Knaden, Mattias Alenius |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-35527-4 |
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