Carbon Nanotubes for Improved Performances of Endodontic Sealer
In order to overcome the limitations of current endodontic sealers, especially against resistant bacteria, recent developments in the field of nanotechnology have proved the necessity to reconsider the composition and physico-chemical properties of classical sealers. Nanoparticles with their unique...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/14/15/4248 |
| _version_ | 1797525409542176768 |
|---|---|
| author | Andreea Marica Luminita Fritea Florin Banica Cosmin Sinescu Ciprian Iovan Iosif Hulka Gerlinde Rusu Simona Cavalu |
| author_facet | Andreea Marica Luminita Fritea Florin Banica Cosmin Sinescu Ciprian Iovan Iosif Hulka Gerlinde Rusu Simona Cavalu |
| author_sort | Andreea Marica |
| collection | DOAJ |
| description | In order to overcome the limitations of current endodontic sealers, especially against resistant bacteria, recent developments in the field of nanotechnology have proved the necessity to reconsider the composition and physico-chemical properties of classical sealers. Nanoparticles with their unique features in terms of small size and high specific surface area, are the best choice for incorporation of antiseptic agents and effective delivery. The aim of our study is to prepare a novel platform for antibacterial drug delivery in dental adhesive systems used in endodontics. For this purpose, multi-walled carbon nanotubes (MWCNTs) encapsulating chlorhexidine (CHX) and colloidal silver nanoparticles (AgNPs) were prepared and incorporated into commercial sealer and investigated in terms of bonding performance to dentin and effectiveness against <i>E. faecalis</i>, <i>S. aureus</i> and <i>Candida albicans</i>, which are responsible for the majority of the failures in endodontic treatments. In this context, the challenges related to the long-term biological effects of CHX/AgNPs loaded MWCNTs are discussed. |
| first_indexed | 2024-03-10T09:12:27Z |
| format | Article |
| id | doaj.art-d1c2476530e845b6b0acee1e7e4b8c7c |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T09:12:27Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-d1c2476530e845b6b0acee1e7e4b8c7c2023-11-22T05:53:53ZengMDPI AGMaterials1996-19442021-07-011415424810.3390/ma14154248Carbon Nanotubes for Improved Performances of Endodontic SealerAndreea Marica0Luminita Fritea1Florin Banica2Cosmin Sinescu3Ciprian Iovan4Iosif Hulka5Gerlinde Rusu6Simona Cavalu7Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, RomaniaFaculty of Dentistry, “Victor Babes” University of Medicine and Pharmacy, P-ta E. Murgu 2, 300041 Timisoara, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, RomaniaResearch Institute for Renewable Energies, University Politehnica Timișoara, G. Muzicescu 138, 300501 Timișoara, RomaniaFaculty of Industrial Chemistry and Environmental Engineering, University Politehnica Timișoara, C. Telbisz 6, 300001 Timișoara, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, RomaniaIn order to overcome the limitations of current endodontic sealers, especially against resistant bacteria, recent developments in the field of nanotechnology have proved the necessity to reconsider the composition and physico-chemical properties of classical sealers. Nanoparticles with their unique features in terms of small size and high specific surface area, are the best choice for incorporation of antiseptic agents and effective delivery. The aim of our study is to prepare a novel platform for antibacterial drug delivery in dental adhesive systems used in endodontics. For this purpose, multi-walled carbon nanotubes (MWCNTs) encapsulating chlorhexidine (CHX) and colloidal silver nanoparticles (AgNPs) were prepared and incorporated into commercial sealer and investigated in terms of bonding performance to dentin and effectiveness against <i>E. faecalis</i>, <i>S. aureus</i> and <i>Candida albicans</i>, which are responsible for the majority of the failures in endodontic treatments. In this context, the challenges related to the long-term biological effects of CHX/AgNPs loaded MWCNTs are discussed.https://www.mdpi.com/1996-1944/14/15/4248endodontic sealerCNTschlorhexidinesilver nanoparticlesantimicrobial |
| spellingShingle | Andreea Marica Luminita Fritea Florin Banica Cosmin Sinescu Ciprian Iovan Iosif Hulka Gerlinde Rusu Simona Cavalu Carbon Nanotubes for Improved Performances of Endodontic Sealer Materials endodontic sealer CNTs chlorhexidine silver nanoparticles antimicrobial |
| title | Carbon Nanotubes for Improved Performances of Endodontic Sealer |
| title_full | Carbon Nanotubes for Improved Performances of Endodontic Sealer |
| title_fullStr | Carbon Nanotubes for Improved Performances of Endodontic Sealer |
| title_full_unstemmed | Carbon Nanotubes for Improved Performances of Endodontic Sealer |
| title_short | Carbon Nanotubes for Improved Performances of Endodontic Sealer |
| title_sort | carbon nanotubes for improved performances of endodontic sealer |
| topic | endodontic sealer CNTs chlorhexidine silver nanoparticles antimicrobial |
| url | https://www.mdpi.com/1996-1944/14/15/4248 |
| work_keys_str_mv | AT andreeamarica carbonnanotubesforimprovedperformancesofendodonticsealer AT luminitafritea carbonnanotubesforimprovedperformancesofendodonticsealer AT florinbanica carbonnanotubesforimprovedperformancesofendodonticsealer AT cosminsinescu carbonnanotubesforimprovedperformancesofendodonticsealer AT ciprianiovan carbonnanotubesforimprovedperformancesofendodonticsealer AT iosifhulka carbonnanotubesforimprovedperformancesofendodonticsealer AT gerlinderusu carbonnanotubesforimprovedperformancesofendodonticsealer AT simonacavalu carbonnanotubesforimprovedperformancesofendodonticsealer |