A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/06262 |
| _version_ | 1818019434308042752 |
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| author | Lea Ankri Zoé Husson Katarzyna Pietrajtis Rémi Proville Clément Léna Yosef Yarom Stéphane Dieudonné Marylka Yoe Uusisaari |
| author_facet | Lea Ankri Zoé Husson Katarzyna Pietrajtis Rémi Proville Clément Léna Yosef Yarom Stéphane Dieudonné Marylka Yoe Uusisaari |
| author_sort | Lea Ankri |
| collection | DOAJ |
| description | The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells. |
| first_indexed | 2024-04-14T07:52:07Z |
| format | Article |
| id | doaj.art-d1c263da458745d4b57a7b842ad9de93 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:52:07Z |
| publishDate | 2015-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d1c263da458745d4b57a7b842ad9de932022-12-22T02:05:10ZengeLife Sciences Publications LtdeLife2050-084X2015-05-01410.7554/eLife.06262A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activityLea Ankri0Zoé Husson1Katarzyna Pietrajtis2Rémi Proville3https://orcid.org/0000-0002-5829-1344Clément Léna4Yosef Yarom5Stéphane Dieudonné6Marylka Yoe Uusisaari7Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelInhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceInhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceCentre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Cerebellum Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceCentre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Cerebellum Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceDepartment of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelInhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceDepartment of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelThe cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.https://elifesciences.org/articles/06262cerebellumcerebellar nucleiGolgi cellinhibition |
| spellingShingle | Lea Ankri Zoé Husson Katarzyna Pietrajtis Rémi Proville Clément Léna Yosef Yarom Stéphane Dieudonné Marylka Yoe Uusisaari A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity eLife cerebellum cerebellar nuclei Golgi cell inhibition |
| title | A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity |
| title_full | A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity |
| title_fullStr | A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity |
| title_full_unstemmed | A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity |
| title_short | A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity |
| title_sort | novel inhibitory nucleo cortical circuit controls cerebellar golgi cell activity |
| topic | cerebellum cerebellar nuclei Golgi cell inhibition |
| url | https://elifesciences.org/articles/06262 |
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