Serotonin Signals Overcome Loser Mentality in Drosophila
Summary: Traumatic experiences generate stressful neurological effects in the exposed persons and animals. Previous studies have demonstrated that in many species, including Drosophila, the defeated animal has a higher probability of losing subsequent fights. However, the neural basis of this “loser...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220308439 |
| _version_ | 1819007174418890752 |
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| author | Shao Wei Hu Yan Tong Yang Yuanjie Sun Yin Peng Zhan Yan Zhu |
| author_facet | Shao Wei Hu Yan Tong Yang Yuanjie Sun Yin Peng Zhan Yan Zhu |
| author_sort | Shao Wei Hu |
| collection | DOAJ |
| description | Summary: Traumatic experiences generate stressful neurological effects in the exposed persons and animals. Previous studies have demonstrated that in many species, including Drosophila, the defeated animal has a higher probability of losing subsequent fights. However, the neural basis of this “loser effect” is largely unknown. We herein report that elevated serotonin (5-HT) signaling helps a loser to overcome suppressive neurological states. Coerced activation of 5-HT neurons increases aggression in males and promotes losers to both vigorously re-engage in fights and even defeat the previous winners and regain mating motivation. P1 neurons act upstream and 5-HT1B neurons in the ellipsoid body act downstream of 5-HT neurons to arouse losers. Our results demonstrate an ancient neural mechanism of regulating depressive behavioral states after distressing events. |
| first_indexed | 2024-12-21T00:20:23Z |
| format | Article |
| id | doaj.art-d1c356973bb946c496c66ef34701d8d6 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-21T00:20:23Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-d1c356973bb946c496c66ef34701d8d62022-12-21T19:22:06ZengElsevieriScience2589-00422020-11-012311101651Serotonin Signals Overcome Loser Mentality in DrosophilaShao Wei Hu0Yan Tong Yang1Yuanjie Sun2Yin Peng Zhan3Yan Zhu4State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China; Sino-Danish Center for Education and Research, Beijing 100190, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China; Corresponding authorSummary: Traumatic experiences generate stressful neurological effects in the exposed persons and animals. Previous studies have demonstrated that in many species, including Drosophila, the defeated animal has a higher probability of losing subsequent fights. However, the neural basis of this “loser effect” is largely unknown. We herein report that elevated serotonin (5-HT) signaling helps a loser to overcome suppressive neurological states. Coerced activation of 5-HT neurons increases aggression in males and promotes losers to both vigorously re-engage in fights and even defeat the previous winners and regain mating motivation. P1 neurons act upstream and 5-HT1B neurons in the ellipsoid body act downstream of 5-HT neurons to arouse losers. Our results demonstrate an ancient neural mechanism of regulating depressive behavioral states after distressing events.http://www.sciencedirect.com/science/article/pii/S2589004220308439Behavioral NeuroscienceMolecular NeuroscienceCellular Neuroscience |
| spellingShingle | Shao Wei Hu Yan Tong Yang Yuanjie Sun Yin Peng Zhan Yan Zhu Serotonin Signals Overcome Loser Mentality in Drosophila iScience Behavioral Neuroscience Molecular Neuroscience Cellular Neuroscience |
| title | Serotonin Signals Overcome Loser Mentality in Drosophila |
| title_full | Serotonin Signals Overcome Loser Mentality in Drosophila |
| title_fullStr | Serotonin Signals Overcome Loser Mentality in Drosophila |
| title_full_unstemmed | Serotonin Signals Overcome Loser Mentality in Drosophila |
| title_short | Serotonin Signals Overcome Loser Mentality in Drosophila |
| title_sort | serotonin signals overcome loser mentality in drosophila |
| topic | Behavioral Neuroscience Molecular Neuroscience Cellular Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220308439 |
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