A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India
Purpose . Advanced cancer patients with disease progression develop cachexia. Nevertheless, cancer patients at nutritional risk have shown improved body weight and quality of life with oral nutritional supplements. Method . This was a randomized controlled trial in adult female cancer patients (n =...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735416651968 |
| _version_ | 1818575960232951808 |
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| author | Neha Kapoor MSc Jane Naufahu PhD Sundus Tewfik PhD Sushma Bhatnagar MD Rakesh Garg MD Ihab Tewfik PhD |
| author_facet | Neha Kapoor MSc Jane Naufahu PhD Sundus Tewfik PhD Sushma Bhatnagar MD Rakesh Garg MD Ihab Tewfik PhD |
| author_sort | Neha Kapoor MSc |
| collection | DOAJ |
| description | Purpose . Advanced cancer patients with disease progression develop cachexia. Nevertheless, cancer patients at nutritional risk have shown improved body weight and quality of life with oral nutritional supplements. Method . This was a randomized controlled trial in adult female cancer patients (n = 63) attending palliative clinics, with symptoms of cachexia. Eligible patients were randomly distributed into control (n = 33) and intervention (n = 30) groups. Both groups were provided with nutritional and physical activity counseling, but the intervention group received an additional 100 g of Improved Atta (IAtta) for 6 months daily consumption. This study was designed to assess the efficacy of IAtta (with counseling) in enhancing the health status of cachexic patients. Anthropometric measurements, dietary intake, physical activity level and quality of life parameters were assessed at baseline, after 3 months, and at the end of 6 months. Results . Patients in the control group (n = 15) had significantly decreased body weight ( P = .003), mid–upper-arm circumference ( P = .002), and body fat ( P = .002) by the end of intervention. A trend of body weight gain in the intervention group (n = 17; P = .08) and significant increase of body fat ( P = .002) was observed; moreover, patients reported a significant improvement in fatigue ( P = .002) and appetite scores ( P = .006) under quality-of-life domains at the end of intervention. Conclusions . Embedding a nutrition-sensitive intervention ( IAtta ) within Indian palliative care therapy may improve quality of life and stabilize body weight in cancer cachexia patients. |
| first_indexed | 2024-12-15T00:47:57Z |
| format | Article |
| id | doaj.art-d1c4084cdfcc4b7a8f09aa9bbe2913f0 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-15T00:47:57Z |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-d1c4084cdfcc4b7a8f09aa9bbe2913f02022-12-21T22:41:30ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2017-03-011610.1177/1534735416651968A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in IndiaNeha Kapoor MSc0Jane Naufahu PhD1Sundus Tewfik PhD2Sushma Bhatnagar MD3Rakesh Garg MD4Ihab Tewfik PhD5University of Westminster, London, UKUniversity of Westminster, London, UKLondon Metropolitan University, London, UKThe All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaThe All India Institute of Medical Sciences (AIIMS), New Delhi, IndiaUniversity of Westminster, London, UKPurpose . Advanced cancer patients with disease progression develop cachexia. Nevertheless, cancer patients at nutritional risk have shown improved body weight and quality of life with oral nutritional supplements. Method . This was a randomized controlled trial in adult female cancer patients (n = 63) attending palliative clinics, with symptoms of cachexia. Eligible patients were randomly distributed into control (n = 33) and intervention (n = 30) groups. Both groups were provided with nutritional and physical activity counseling, but the intervention group received an additional 100 g of Improved Atta (IAtta) for 6 months daily consumption. This study was designed to assess the efficacy of IAtta (with counseling) in enhancing the health status of cachexic patients. Anthropometric measurements, dietary intake, physical activity level and quality of life parameters were assessed at baseline, after 3 months, and at the end of 6 months. Results . Patients in the control group (n = 15) had significantly decreased body weight ( P = .003), mid–upper-arm circumference ( P = .002), and body fat ( P = .002) by the end of intervention. A trend of body weight gain in the intervention group (n = 17; P = .08) and significant increase of body fat ( P = .002) was observed; moreover, patients reported a significant improvement in fatigue ( P = .002) and appetite scores ( P = .006) under quality-of-life domains at the end of intervention. Conclusions . Embedding a nutrition-sensitive intervention ( IAtta ) within Indian palliative care therapy may improve quality of life and stabilize body weight in cancer cachexia patients.https://doi.org/10.1177/1534735416651968 |
| spellingShingle | Neha Kapoor MSc Jane Naufahu PhD Sundus Tewfik PhD Sushma Bhatnagar MD Rakesh Garg MD Ihab Tewfik PhD A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India Integrative Cancer Therapies |
| title | A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India |
| title_full | A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India |
| title_fullStr | A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India |
| title_full_unstemmed | A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India |
| title_short | A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India |
| title_sort | prospective randomized controlled trial to study the impact of a nutrition sensitive intervention on adult women with cancer cachexia undergoing palliative care in india |
| url | https://doi.org/10.1177/1534735416651968 |
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