MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.

MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.

Double-strand breaks (DSBs) constitute the most deleterious form of DNA lesions that can lead to genome alterations and cell death, and the vast majority of DSBs arise pathologically in response to DNA damaging agents such as ionizing radiation (IR) and chemotherapeutic agents. Recent studies have i...

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Bibliographic Details
Main Authors: Xiling Wu, Yang Xu, Katey Feng, Joshua D Tompkins, Chengtao Her
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3762724?pdf=render

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