Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review
As the prevalence of dementia increases from year to year, the discovery and invention of preventive measures are growing increasingly urgent. Banana peels contain tryptophan, an amino acid that plays a substantial role in the mechanism of dementia prevention, yet under-utilized for this purpose. Tr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine
2021-08-01
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| Series: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| Subjects: | |
| Online Access: | https://journal.uii.ac.id/JKKI/article/view/16861 |
| _version_ | 1797785402367541248 |
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| author | Daffara Kinanthi Lustikaiswi Sapto Yuliani Rahmah Annura Elmi Rahmadani |
| author_facet | Daffara Kinanthi Lustikaiswi Sapto Yuliani Rahmah Annura Elmi Rahmadani |
| author_sort | Daffara Kinanthi Lustikaiswi |
| collection | DOAJ |
| description | As the prevalence of dementia increases from year to year, the discovery and invention of preventive measures are growing increasingly urgent. Banana peels contain tryptophan, an amino acid that plays a substantial role in the mechanism of dementia prevention, yet under-utilized for this purpose. Tryptophan acts as a precursor to serotonin and kynurenine. The serotonin metabolite, 5-hydroxyindoleacetate or 5-hydroxyindoleacetic acid (5-HIAA), can degrade amyloid-ß (Aß) oligomers, a peptide group of 36–43 amino acids derived from amyloid precursor protein found in people with Alzheimer's disease. The degradation of brain cells through the increase of neprilysin (NEP) and melatonin inhibits glycogen synthase kinase-3ß (GSK3ß) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?ß) by reducing the decrease in peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1). Meanwhile, in the kynurenine pathway, kynurenic acid (KYNA) also induces the NEP gene, thus preventing Aß. |
| first_indexed | 2024-03-13T00:54:35Z |
| format | Article |
| id | doaj.art-d1c50e9dab1f4748847321301192fafb |
| institution | Directory Open Access Journal |
| issn | 2085-4145 2527-2950 |
| language | English |
| last_indexed | 2024-03-13T00:54:35Z |
| publishDate | 2021-08-01 |
| publisher | Faculty of Medicine |
| record_format | Article |
| series | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| spelling | doaj.art-d1c50e9dab1f4748847321301192fafb2023-07-07T07:41:36ZengFaculty of MedicineJKKI (Jurnal Kedokteran dan Kesehatan Indonesia)2085-41452527-29502021-08-0117518110.20885/JKKI.Vol12.Iss2.art1113420Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative reviewDaffara Kinanthi Lustikaiswi0Sapto Yuliani1Rahmah Annura2Elmi Rahmadani3Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaFaculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaFaculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaFaculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaAs the prevalence of dementia increases from year to year, the discovery and invention of preventive measures are growing increasingly urgent. Banana peels contain tryptophan, an amino acid that plays a substantial role in the mechanism of dementia prevention, yet under-utilized for this purpose. Tryptophan acts as a precursor to serotonin and kynurenine. The serotonin metabolite, 5-hydroxyindoleacetate or 5-hydroxyindoleacetic acid (5-HIAA), can degrade amyloid-ß (Aß) oligomers, a peptide group of 36–43 amino acids derived from amyloid precursor protein found in people with Alzheimer's disease. The degradation of brain cells through the increase of neprilysin (NEP) and melatonin inhibits glycogen synthase kinase-3ß (GSK3ß) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?ß) by reducing the decrease in peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1). Meanwhile, in the kynurenine pathway, kynurenic acid (KYNA) also induces the NEP gene, thus preventing Aß.https://journal.uii.ac.id/JKKI/article/view/16861banana peeltryptophandementia |
| spellingShingle | Daffara Kinanthi Lustikaiswi Sapto Yuliani Rahmah Annura Elmi Rahmadani Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) banana peel tryptophan dementia |
| title | Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review |
| title_full | Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review |
| title_fullStr | Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review |
| title_full_unstemmed | Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review |
| title_short | Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review |
| title_sort | tryptophan in banana peel musa paradisiaca as an anti dementia alternative treatment a narrative review |
| topic | banana peel tryptophan dementia |
| url | https://journal.uii.ac.id/JKKI/article/view/16861 |
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