Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.
Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palm...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0198149 |
| _version_ | 1818677995516198912 |
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| author | Katrin Strassburger Evangeline Kang Aurelio A Teleman |
| author_facet | Katrin Strassburger Evangeline Kang Aurelio A Teleman |
| author_sort | Katrin Strassburger |
| collection | DOAJ |
| description | Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8. |
| first_indexed | 2024-12-17T09:08:14Z |
| format | Article |
| id | doaj.art-d1c56f53871643a2a546524fce1032d5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:08:14Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d1c56f53871643a2a546524fce1032d52022-12-21T21:55:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01142e019814910.1371/journal.pone.0198149Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.Katrin StrassburgerEvangeline KangAurelio A TelemanPalmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8.https://doi.org/10.1371/journal.pone.0198149 |
| spellingShingle | Katrin Strassburger Evangeline Kang Aurelio A Teleman Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. PLoS ONE |
| title | Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. |
| title_full | Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. |
| title_fullStr | Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. |
| title_full_unstemmed | Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. |
| title_short | Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability. |
| title_sort | drosophila zdhhc8 palmitoylates scribble and ras64b and controls growth and viability |
| url | https://doi.org/10.1371/journal.pone.0198149 |
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