DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer
Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas (TCGA) and TISIDB databases from stomach adenoca...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402302265X |
| _version_ | 1797836980921303040 |
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| author | Shiyao Zheng Yongyuan Chen Shiya Yu Caiming Weng Nan Lin Ziqiang Luo Yuanzhao Wang Ping Xiong Zhun Teng Yu Wang Hu Zhao Chunhong Xiao |
| author_facet | Shiyao Zheng Yongyuan Chen Shiya Yu Caiming Weng Nan Lin Ziqiang Luo Yuanzhao Wang Ping Xiong Zhun Teng Yu Wang Hu Zhao Chunhong Xiao |
| author_sort | Shiyao Zheng |
| collection | DOAJ |
| description | Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas (TCGA) and TISIDB databases from stomach adenocarcinoma (STAD) patients, which revealed that DISC1 overexpression was closely associated with tumor histological type (mucinous vs. tubular, OR = 2.860, CI = 1.423–5.872, p = 0.004), as well as tumor stage and grade. Furthermore, the higher the DISC1 expression, the lower the overall 10-year survival rate. Patients with low DISC1 expression had a significantly longer progression-free interval (PFI) and disease-specific survival (DSS) than patients with high DISC1 expression. However, patients with higher DISC1 expression in the T3&T4, N0&N1 and M0 subgroups had poorer prognosis in terms of OS, DSS and PFI, as could be seen in the subgroup survival analysis. Public datasets were used to predict lncRNA-miRNA-DISC1 regulation. DISC1 was significantly up-regulated in GC(gastric cancer), and its expression levels showed a moderate to strong positive correlation with infiltration levels of effector memory T cells (Tem) and central memory T cells (Tcm), and a negative correlation was observed with Th17 cells and NK CD56bright cells. In addition, concomitant with the high expression of the DISC1 gene was a decrease in MHC-I (Major Histocompatibility Complex-I)expression and an increase in MHC-II expression, and altered chemokine expression. The upregulation of CXCL12 and CXCR4 expression could be caused by an increase in DISC1 expression.The above expression variability and correlation suggest a role for DISC1 in regulating tumor immunity in GC. These findings suggest that high expression of DISC1 could be an independent prognostic factor for GC. |
| first_indexed | 2024-04-09T15:18:42Z |
| format | Article |
| id | doaj.art-d1c8fae34ca34c958e279a3140042cfc |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:18:42Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d1c8fae34ca34c958e279a3140042cfc2023-04-29T14:54:49ZengElsevierHeliyon2405-84402023-04-0194e15058DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancerShiyao Zheng0Yongyuan Chen1Shiya Yu2Caiming Weng3Nan Lin4Ziqiang Luo5Yuanzhao Wang6Ping Xiong7Zhun Teng8Yu Wang9Hu Zhao10Chunhong Xiao11Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; College of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, Fujian, 350004, Fujian, PR ChinaFuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR ChinaFuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR ChinaFuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR ChinaFuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR ChinaDepartment of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, Xiamen University, Fuzhou, 350025, Fujian, PR ChinaDepartment of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, Xiamen University, Fuzhou, 350025, Fujian, PR ChinaDepartment of Obstetrics and Gynecology, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, 350025, Fujian, PR ChinaDepartment of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR ChinaFuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR China; Corresponding author. 156 Xierhuan Northern Road, Fuzhou 350025, China.Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR China; Corresponding author. Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China.Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China; Department of General Surgery, 900 Hospital of the Joint Logistics Support Force, 156 Xierhuan Road, Fuzhou, Fujian, 350025, Fujian, PR China; Corresponding author. Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, 350025, Fujian, PR China.Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. We extracted data from the Cancer Genome Atlas (TCGA) and TISIDB databases from stomach adenocarcinoma (STAD) patients, which revealed that DISC1 overexpression was closely associated with tumor histological type (mucinous vs. tubular, OR = 2.860, CI = 1.423–5.872, p = 0.004), as well as tumor stage and grade. Furthermore, the higher the DISC1 expression, the lower the overall 10-year survival rate. Patients with low DISC1 expression had a significantly longer progression-free interval (PFI) and disease-specific survival (DSS) than patients with high DISC1 expression. However, patients with higher DISC1 expression in the T3&T4, N0&N1 and M0 subgroups had poorer prognosis in terms of OS, DSS and PFI, as could be seen in the subgroup survival analysis. Public datasets were used to predict lncRNA-miRNA-DISC1 regulation. DISC1 was significantly up-regulated in GC(gastric cancer), and its expression levels showed a moderate to strong positive correlation with infiltration levels of effector memory T cells (Tem) and central memory T cells (Tcm), and a negative correlation was observed with Th17 cells and NK CD56bright cells. In addition, concomitant with the high expression of the DISC1 gene was a decrease in MHC-I (Major Histocompatibility Complex-I)expression and an increase in MHC-II expression, and altered chemokine expression. The upregulation of CXCL12 and CXCR4 expression could be caused by an increase in DISC1 expression.The above expression variability and correlation suggest a role for DISC1 in regulating tumor immunity in GC. These findings suggest that high expression of DISC1 could be an independent prognostic factor for GC.http://www.sciencedirect.com/science/article/pii/S240584402302265XDISC1Gastric cancerTumor infiltrating lymphocytesBioinformaticsPrognosis |
| spellingShingle | Shiyao Zheng Yongyuan Chen Shiya Yu Caiming Weng Nan Lin Ziqiang Luo Yuanzhao Wang Ping Xiong Zhun Teng Yu Wang Hu Zhao Chunhong Xiao DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer Heliyon DISC1 Gastric cancer Tumor infiltrating lymphocytes Bioinformatics Prognosis |
| title | DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer |
| title_full | DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer |
| title_fullStr | DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer |
| title_full_unstemmed | DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer |
| title_short | DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer |
| title_sort | disc1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer |
| topic | DISC1 Gastric cancer Tumor infiltrating lymphocytes Bioinformatics Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S240584402302265X |
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