Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release
Drug-loaded mono- and multilayer composite membranes were prepared. The composites, based on nano-fibrillated bacterial cellulose, nano-powdered bacterial cellulose, and polyvinyl alcohol, all biocompatible and biodegradable, were characterized in terms of basic factors related to drug diffusivity a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/2/1015 |
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| author | Cristina Busuioc Gabriela Olimpia Isopencu Iuliana-Mihaela Deleanu |
| author_facet | Cristina Busuioc Gabriela Olimpia Isopencu Iuliana-Mihaela Deleanu |
| author_sort | Cristina Busuioc |
| collection | DOAJ |
| description | Drug-loaded mono- and multilayer composite membranes were prepared. The composites, based on nano-fibrillated bacterial cellulose, nano-powdered bacterial cellulose, and polyvinyl alcohol, all biocompatible and biodegradable, were characterized in terms of basic factors related to drug diffusivity and mass transfer: swelling ability, water solubility, and water vapor permeability. Tetracycline hydrochloride was used in this case as drug model. Drug release was evaluated in an aqueous environment for two concentration levels of the antibiotic, and mathematical modeling was applied to fit experimental data. Tetracycline release was influenced by a membranes’ structure, layers’ composition, and by a membranes’ thickness. Bacterial cellulose nanofibrils proved to be the key factor in achieving suitable drug release profiles. Thus, sustained antibiotic delivery was obtained for several days in the case of multilayer composites. The composites proved drug stability and antibacterial efficiency before and after TC-HCl continuous release for several days. |
| first_indexed | 2024-03-09T13:42:41Z |
| format | Article |
| id | doaj.art-d1ca10e57dd845bd9af1f757a57cf9f1 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T13:42:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-d1ca10e57dd845bd9af1f757a57cf9f12023-11-30T21:04:57ZengMDPI AGApplied Sciences2076-34172023-01-01132101510.3390/app13021015Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug ReleaseCristina Busuioc0Gabriela Olimpia Isopencu1Iuliana-Mihaela Deleanu2University Politehnica of Bucharest, RO-060042 Bucharest, RomaniaUniversity Politehnica of Bucharest, RO-060042 Bucharest, RomaniaUniversity Politehnica of Bucharest, RO-060042 Bucharest, RomaniaDrug-loaded mono- and multilayer composite membranes were prepared. The composites, based on nano-fibrillated bacterial cellulose, nano-powdered bacterial cellulose, and polyvinyl alcohol, all biocompatible and biodegradable, were characterized in terms of basic factors related to drug diffusivity and mass transfer: swelling ability, water solubility, and water vapor permeability. Tetracycline hydrochloride was used in this case as drug model. Drug release was evaluated in an aqueous environment for two concentration levels of the antibiotic, and mathematical modeling was applied to fit experimental data. Tetracycline release was influenced by a membranes’ structure, layers’ composition, and by a membranes’ thickness. Bacterial cellulose nanofibrils proved to be the key factor in achieving suitable drug release profiles. Thus, sustained antibiotic delivery was obtained for several days in the case of multilayer composites. The composites proved drug stability and antibacterial efficiency before and after TC-HCl continuous release for several days.https://www.mdpi.com/2076-3417/13/2/1015polyvinyl alcoholbacterial cellulosemultilayer compositesdiffusioncontrolled releasemathematical modeling |
| spellingShingle | Cristina Busuioc Gabriela Olimpia Isopencu Iuliana-Mihaela Deleanu Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release Applied Sciences polyvinyl alcohol bacterial cellulose multilayer composites diffusion controlled release mathematical modeling |
| title | Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release |
| title_full | Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release |
| title_fullStr | Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release |
| title_full_unstemmed | Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release |
| title_short | Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release |
| title_sort | bacterial cellulose polyvinyl alcohol based complex composites for controlled drug release |
| topic | polyvinyl alcohol bacterial cellulose multilayer composites diffusion controlled release mathematical modeling |
| url | https://www.mdpi.com/2076-3417/13/2/1015 |
| work_keys_str_mv | AT cristinabusuioc bacterialcellulosepolyvinylalcoholbasedcomplexcompositesforcontrolleddrugrelease AT gabrielaolimpiaisopencu bacterialcellulosepolyvinylalcoholbasedcomplexcompositesforcontrolleddrugrelease AT iulianamihaeladeleanu bacterialcellulosepolyvinylalcoholbasedcomplexcompositesforcontrolleddrugrelease |