Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy

Background: Current mainstream treatment of major depressive disorder (MDD) has a disadvantage in delayed onset of efficacy, making detection of early signatures predicative of the long-term treatment efficacy urgent.Methods: MDD patients were scored with HAMD-24 and serum brain-derived neurotrophic...

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Main Authors: Yuxuan Zhang, Bo Cui, Tianyu Wang, Yan Lu, Zhenlin Chen, Zhilu Zou, Jinlin Miao, Xiuli Zhao, Yonggui Yuan, Haosen Wang, Gang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.712445/full
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author Yuxuan Zhang
Bo Cui
Tianyu Wang
Tianyu Wang
Yan Lu
Zhenlin Chen
Zhilu Zou
Jinlin Miao
Xiuli Zhao
Yonggui Yuan
Yonggui Yuan
Haosen Wang
Gang Chen
Gang Chen
author_facet Yuxuan Zhang
Bo Cui
Tianyu Wang
Tianyu Wang
Yan Lu
Zhenlin Chen
Zhilu Zou
Jinlin Miao
Xiuli Zhao
Yonggui Yuan
Yonggui Yuan
Haosen Wang
Gang Chen
Gang Chen
author_sort Yuxuan Zhang
collection DOAJ
description Background: Current mainstream treatment of major depressive disorder (MDD) has a disadvantage in delayed onset of efficacy, making detection of early signatures predicative of the long-term treatment efficacy urgent.Methods: MDD patients were scored with HAMD-24 and serum brain-derived neurotrophic factor (BDNF) levels were measured at different times in two independent trials: a single-arm observation of Yueju pill, a clinically approved traditional multiherbal medicine, and a two-arm random placebo-controlled trial for Yueju vs escitalopram. The ratio of the BDNF level to HAMD-24 score, or neuroplasticity index (NI), and its derived parameters were used for correlation analysis and receiver operating characteristic (ROC) analysis.Results: On both the early (4th) and final (28th) days, Yueju and escitalopram significantly reduced HAMD-24 scores, compared to baselines, but only Yueju increased BDNF at both times. For either Yueju or escitalopram treatment, NI, but not BDNF, at baseline was correlated to NIs at the early or final treatment day. NI at early time was significantly correlated to early NI enhancement from the baseline for both Yueju and escitalopram, and to final NI enhancement from the baseline for Yueju in both trials. ROC analysis supported the predictability of Yueju’s final treatment efficacy from early NI enhancement.Limitations: The small sample size and 28 days of treatment time may lead to the impossibility of ROC analysis of escitalopram.Conclusion: Early NI enhancement is useful for prediction of long-term efficacy of Yueju and presumably some other antidepressants.Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [ChiCTR1900021114].
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spelling doaj.art-d1cc0506248c41b78195bd5e706deb212022-12-21T19:21:45ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-10-011510.3389/fnbeh.2021.712445712445Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant EfficacyYuxuan Zhang0Bo Cui1Tianyu Wang2Tianyu Wang3Yan Lu4Zhenlin Chen5Zhilu Zou6Jinlin Miao7Xiuli Zhao8Yonggui Yuan9Yonggui Yuan10Haosen Wang11Gang Chen12Gang Chen13Key Laboratory of Integrative Biomedicine for Brain Diseases, Center for Translational Systems Biology and Neuroscience, Nanjing University of Chinese Medicine, Nanjing, ChinaInterdisciplinary Institute for Personalized Medicine in Brain Disorders, Jinan University, Guangzhou, ChinaDepartment of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, ChinaSchool of Medicine, Institute of Psychosomatics, Southeast University, Nanjing, ChinaThe Fourth People’s Hospital of Taizhou, Taizhou, ChinaThe Fourth People’s Hospital of Taizhou, Taizhou, ChinaHubei University of Chinese Medicine, Wuhan, ChinaThe Fourth People’s Hospital of Taizhou, Taizhou, ChinaThe Fourth People’s Hospital of Taizhou, Taizhou, ChinaDepartment of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, ChinaSchool of Medicine, Institute of Psychosomatics, Southeast University, Nanjing, ChinaThe Fourth People’s Hospital of Taizhou, Taizhou, ChinaInterdisciplinary Institute for Personalized Medicine in Brain Disorders, Jinan University, Guangzhou, ChinaCo-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaBackground: Current mainstream treatment of major depressive disorder (MDD) has a disadvantage in delayed onset of efficacy, making detection of early signatures predicative of the long-term treatment efficacy urgent.Methods: MDD patients were scored with HAMD-24 and serum brain-derived neurotrophic factor (BDNF) levels were measured at different times in two independent trials: a single-arm observation of Yueju pill, a clinically approved traditional multiherbal medicine, and a two-arm random placebo-controlled trial for Yueju vs escitalopram. The ratio of the BDNF level to HAMD-24 score, or neuroplasticity index (NI), and its derived parameters were used for correlation analysis and receiver operating characteristic (ROC) analysis.Results: On both the early (4th) and final (28th) days, Yueju and escitalopram significantly reduced HAMD-24 scores, compared to baselines, but only Yueju increased BDNF at both times. For either Yueju or escitalopram treatment, NI, but not BDNF, at baseline was correlated to NIs at the early or final treatment day. NI at early time was significantly correlated to early NI enhancement from the baseline for both Yueju and escitalopram, and to final NI enhancement from the baseline for Yueju in both trials. ROC analysis supported the predictability of Yueju’s final treatment efficacy from early NI enhancement.Limitations: The small sample size and 28 days of treatment time may lead to the impossibility of ROC analysis of escitalopram.Conclusion: Early NI enhancement is useful for prediction of long-term efficacy of Yueju and presumably some other antidepressants.Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [ChiCTR1900021114].https://www.frontiersin.org/articles/10.3389/fnbeh.2021.712445/fullYueju pillBDNFantidepressant efficacypredictionneuroplasticity index
spellingShingle Yuxuan Zhang
Bo Cui
Tianyu Wang
Tianyu Wang
Yan Lu
Zhenlin Chen
Zhilu Zou
Jinlin Miao
Xiuli Zhao
Yonggui Yuan
Yonggui Yuan
Haosen Wang
Gang Chen
Gang Chen
Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy
Frontiers in Behavioral Neuroscience
Yueju pill
BDNF
antidepressant efficacy
prediction
neuroplasticity index
title Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy
title_full Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy
title_fullStr Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy
title_full_unstemmed Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy
title_short Early Enhancement of Neuroplasticity Index, the Ratio of Serum Brain-Derived Neurotrophic Factor Level to HAMD-24 Score, in Predicting the Long-Term Antidepressant Efficacy
title_sort early enhancement of neuroplasticity index the ratio of serum brain derived neurotrophic factor level to hamd 24 score in predicting the long term antidepressant efficacy
topic Yueju pill
BDNF
antidepressant efficacy
prediction
neuroplasticity index
url https://www.frontiersin.org/articles/10.3389/fnbeh.2021.712445/full
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