Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummary
Liver cancer (hepatocellular carcinoma [HCC]) is a fatal cancer worldwide and often is detected at an advanced stage when treatment options are very limited. This drives the development of techniques and platforms for early detection of HCC. In recent years, liquid biopsy has provided a means of non...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X22000352 |
| _version_ | 1818206904622514176 |
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| author | Xueying Lyu Yu-Man Tsui Daniel Wai-Hung Ho Irene Oi-Lin Ng |
| author_facet | Xueying Lyu Yu-Man Tsui Daniel Wai-Hung Ho Irene Oi-Lin Ng |
| author_sort | Xueying Lyu |
| collection | DOAJ |
| description | Liver cancer (hepatocellular carcinoma [HCC]) is a fatal cancer worldwide and often is detected at an advanced stage when treatment options are very limited. This drives the development of techniques and platforms for early detection of HCC. In recent years, liquid biopsy has provided a means of noninvasive detection of cancers. By detecting plasma circulating tumor DNA (ctDNA) released from dying cancer cells, the presence of HCC can be detected in a noninvasive manner. In this review, we discuss the molecular characteristics of ctDNA and its various molecular landscapes in HCC. These include the mutational landscape, single-nucleotide variations, copy number variations, methylation landscape, end motif/coordinate preference, hepatitis B virus integration, and mitochondrial DNA mutations. The consistency between the plasma ctDNA and the tumor tissue genomic DNA mutational profile is pivotal for the clinical utility of ctDNA in the clinical management of HCC. With strategic use of genetic information provided from plasma ctDNA profiling and procedure standardization to facilitate implementation in clinical practice, better clinical management would become permissible through more efficient detection and diagnosis of HCC, better prognostication, precision-matched treatment guidance, and more reliable disease monitoring. |
| first_indexed | 2024-12-12T04:20:26Z |
| format | Article |
| id | doaj.art-d1cc457c1c0845fd8e06a467094caf86 |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-12-12T04:20:26Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-d1cc457c1c0845fd8e06a467094caf862022-12-22T00:38:20ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2022-01-0113616111624Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummaryXueying Lyu0Yu-Man Tsui1Daniel Wai-Hung Ho2Irene Oi-Lin Ng3Department of Pathology and State Key Laboratory of Liver Research, The University of Hong Kong, Hong KongDepartment of Pathology and State Key Laboratory of Liver Research, The University of Hong Kong, Hong KongCorrespondence Address correspondence to: Daniel Wai-Hung Ho, PhD, Department of Pathology, L704, Laboratory Block, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong. fax: (852) 2819-5375.; Department of Pathology and State Key Laboratory of Liver Research, The University of Hong Kong, Hong KongIrene Oi-Lin Ng, MD, PhD, Department of Pathology, Room 7-13, Block T, Queen Mary Hospital, Pokfulam, Hong Kong. fax: 852-28872-5197.; Department of Pathology and State Key Laboratory of Liver Research, The University of Hong Kong, Hong KongLiver cancer (hepatocellular carcinoma [HCC]) is a fatal cancer worldwide and often is detected at an advanced stage when treatment options are very limited. This drives the development of techniques and platforms for early detection of HCC. In recent years, liquid biopsy has provided a means of noninvasive detection of cancers. By detecting plasma circulating tumor DNA (ctDNA) released from dying cancer cells, the presence of HCC can be detected in a noninvasive manner. In this review, we discuss the molecular characteristics of ctDNA and its various molecular landscapes in HCC. These include the mutational landscape, single-nucleotide variations, copy number variations, methylation landscape, end motif/coordinate preference, hepatitis B virus integration, and mitochondrial DNA mutations. The consistency between the plasma ctDNA and the tumor tissue genomic DNA mutational profile is pivotal for the clinical utility of ctDNA in the clinical management of HCC. With strategic use of genetic information provided from plasma ctDNA profiling and procedure standardization to facilitate implementation in clinical practice, better clinical management would become permissible through more efficient detection and diagnosis of HCC, better prognostication, precision-matched treatment guidance, and more reliable disease monitoring.http://www.sciencedirect.com/science/article/pii/S2352345X22000352Cell-Free DNACirculating Tumor DNAHepatocellular Carcinoma |
| spellingShingle | Xueying Lyu Yu-Man Tsui Daniel Wai-Hung Ho Irene Oi-Lin Ng Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummary Cellular and Molecular Gastroenterology and Hepatology Cell-Free DNA Circulating Tumor DNA Hepatocellular Carcinoma |
| title | Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummary |
| title_full | Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummary |
| title_fullStr | Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummary |
| title_full_unstemmed | Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummary |
| title_short | Liquid Biopsy Using Cell-Free or Circulating Tumor DNA in the Management of Hepatocellular CarcinomaSummary |
| title_sort | liquid biopsy using cell free or circulating tumor dna in the management of hepatocellular carcinomasummary |
| topic | Cell-Free DNA Circulating Tumor DNA Hepatocellular Carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X22000352 |
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