CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseases
CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRIS...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00030/full |
| _version_ | 1818019900838379520 |
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| author | Weili eYang Zhuchi eTu Qiang eSun Xiao-Jiang eLi |
| author_facet | Weili eYang Zhuchi eTu Qiang eSun Xiao-Jiang eLi |
| author_sort | Weili eYang |
| collection | DOAJ |
| description | CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative diseases, such as Parkinson’s and Huntington's diseases, and to treat these disorders that are caused by genetic mutations. |
| first_indexed | 2024-04-14T07:58:52Z |
| format | Article |
| id | doaj.art-d1d24be462f94e678935ef041c7ef69b |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-14T07:58:52Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-d1d24be462f94e678935ef041c7ef69b2022-12-22T02:04:58ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992016-04-01910.3389/fnmol.2016.00030197797CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseasesWeili eYang0Zhuchi eTu1Qiang eSun2Xiao-Jiang eLi3Institute of Genetics and Developmental BiologyInstitute of Genetics and Developmental BiologyInstitute of Genetics and Developmental BiologyEmory University School of MedicineCRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative diseases, such as Parkinson’s and Huntington's diseases, and to treat these disorders that are caused by genetic mutations.http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00030/fullGene TherapyNeurodegenerative DiseasesAnimal ModelsCRISPR/Cas9Genetic mutations |
| spellingShingle | Weili eYang Zhuchi eTu Qiang eSun Xiao-Jiang eLi CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseases Frontiers in Molecular Neuroscience Gene Therapy Neurodegenerative Diseases Animal Models CRISPR/Cas9 Genetic mutations |
| title | CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseases |
| title_full | CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseases |
| title_fullStr | CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseases |
| title_full_unstemmed | CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseases |
| title_short | CRISPR/Cas9: implications for modeling and therapy of neurodegenerative diseases |
| title_sort | crispr cas9 implications for modeling and therapy of neurodegenerative diseases |
| topic | Gene Therapy Neurodegenerative Diseases Animal Models CRISPR/Cas9 Genetic mutations |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00030/full |
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