PBP-A, a cyanobacterial dd-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to Escherichia coli

PBP-A, a cyanobacterial dd-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to Escherichia coli

Abstract Penicillin binding proteins (PBPs) are involved in biosynthesis, remodeling and recycling of peptidoglycan (PG) in bacteria. PBP-A from Thermosynechococcus elongatus belongs to a cyanobacterial family of enzymes sharing close structural and phylogenetic proximity to class A β-lactamases. Wi...

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Bibliographische Detailangaben
Hauptverfasser: Gol Mohammad Dorrazehi, Matthias Winkle, Martin Desmet, Vincent Stroobant, Gamze Tanriver, Hervé Degand, Damien Evrard, Benoît Desguin, Pierre Morsomme, Jacob Biboy, Joe Gray, Karolina Mitusińska, Artur Góra, Waldemar Vollmer, Patrice Soumillion
Format: Artikel
Sprache:English
Veröffentlicht: Nature Portfolio 2024-06-01
Schriftenreihe:Scientific Reports
Online Zugang:https://doi.org/10.1038/s41598-024-64806-x

Online

https://doi.org/10.1038/s41598-024-64806-x

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