Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort Study
Patients with bullous pemphigoid are susceptible to serious infections, which are the leading cause of death in these patients. The aims of this population-based cohort study were to investigate the incidence and spectrum of serious infections in patients with bullous pemphigoid and to identify asso...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2023-06-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/5329 |
| _version_ | 1827932791288889344 |
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| author | Tsung-Hsien Chang Chun-Ying Wu Yun-Ting Chang Ying-Syuan Lyu Chen-Yi Wu |
| author_facet | Tsung-Hsien Chang Chun-Ying Wu Yun-Ting Chang Ying-Syuan Lyu Chen-Yi Wu |
| author_sort | Tsung-Hsien Chang |
| collection | DOAJ |
| description | Patients with bullous pemphigoid are susceptible to serious infections, which are the leading cause of death in these patients. The aims of this population-based cohort study were to investigate the incidence and spectrum of serious infections in patients with bullous pemphigoid and to identify associated risk factors. The outcome measure was any infection requiring hospitalization. Hazard ratios with 95% confidence intervals were estimated using subdistribution hazard models. In total, 12,300 patients with bullous pemphigoid and 49,200 matched controls were identified through the National Health Insurance Research Database in Taiwan. Within 2 years of bullous pemphigoid diagnosis, 5,006 (40.7%) patients developed serious infections, with an incidence of 385.5/1,000 person-years. Patients with bullous pemphigoid were twice as likely to develop serious infections as controls (adjusted hazard ratio, 2.01; 95% confidence interval 1.92–2.10). Systemic corticosteroid use was the strongest risk factor, resulting in a 2-fold increase in the risk for serious infections. Other independent risk factors were advanced age, female sex, low income, and certain comorbidities. In conclusion, this study demonstrated an increased risk of serious infections following a diagnosis of bullous pemphigoid. Prophylaxis of serious infections through active intervention with the risk factors may be essential in reducing the morbidity and mortality associated with bullous pemphigoid.
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| first_indexed | 2024-03-13T07:15:25Z |
| format | Article |
| id | doaj.art-d1d38e4f7d444a4085152b20711200a3 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-03-13T07:15:25Z |
| publishDate | 2023-06-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-d1d38e4f7d444a4085152b20711200a32023-06-05T08:33:21ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572023-06-0110310.2340/actadv.v103.5329Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort StudyTsung-Hsien Chang0Chun-Ying Wu1Yun-Ting Chang2Ying-Syuan Lyu3Chen-Yi Wu4Department of Dermatology, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Translational Research, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Dermatology, Taipei Veterans General Hospital, Taipei, TaiwanDivision of Translational Research, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Dermatology, Taipei Veterans General Hospital, Taipei, TaiwanPatients with bullous pemphigoid are susceptible to serious infections, which are the leading cause of death in these patients. The aims of this population-based cohort study were to investigate the incidence and spectrum of serious infections in patients with bullous pemphigoid and to identify associated risk factors. The outcome measure was any infection requiring hospitalization. Hazard ratios with 95% confidence intervals were estimated using subdistribution hazard models. In total, 12,300 patients with bullous pemphigoid and 49,200 matched controls were identified through the National Health Insurance Research Database in Taiwan. Within 2 years of bullous pemphigoid diagnosis, 5,006 (40.7%) patients developed serious infections, with an incidence of 385.5/1,000 person-years. Patients with bullous pemphigoid were twice as likely to develop serious infections as controls (adjusted hazard ratio, 2.01; 95% confidence interval 1.92–2.10). Systemic corticosteroid use was the strongest risk factor, resulting in a 2-fold increase in the risk for serious infections. Other independent risk factors were advanced age, female sex, low income, and certain comorbidities. In conclusion, this study demonstrated an increased risk of serious infections following a diagnosis of bullous pemphigoid. Prophylaxis of serious infections through active intervention with the risk factors may be essential in reducing the morbidity and mortality associated with bullous pemphigoid. https://medicaljournalssweden.se/actadv/article/view/5329Bullous pemphigoidCohort StudiesInfectionsPneumoniaSepsisVesiculobullous skin disease |
| spellingShingle | Tsung-Hsien Chang Chun-Ying Wu Yun-Ting Chang Ying-Syuan Lyu Chen-Yi Wu Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort Study Acta Dermato-Venereologica Bullous pemphigoid Cohort Studies Infections Pneumonia Sepsis Vesiculobullous skin disease |
| title | Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort Study |
| title_full | Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort Study |
| title_fullStr | Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort Study |
| title_full_unstemmed | Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort Study |
| title_short | Risk of Serious Infections in Patients with Bullous Pemphigoid: A Population-based Cohort Study |
| title_sort | risk of serious infections in patients with bullous pemphigoid a population based cohort study |
| topic | Bullous pemphigoid Cohort Studies Infections Pneumonia Sepsis Vesiculobullous skin disease |
| url | https://medicaljournalssweden.se/actadv/article/view/5329 |
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