Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

Summary: Background: Immunoglobulin G1 (IgG1) effector functions are impacted by the structure of fragment crystallizable (Fc) tail-linked N-glycans. Low fucosylation levels on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein-specific IgG1 has been described as a hallm...

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Bibliographic Details
Main Authors: Tamas Pongracz, Jan Nouta, Wenjun Wang, Krista E. van Meijgaarden, Federica Linty, Gestur Vidarsson, Simone A. Joosten, Tom H.M. Ottenhoff, Cornelis H. Hokke, Jutte J.C. de Vries, Sesmu M. Arbous, Anna H.E. Roukens, Manfred Wuhrer
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:EBioMedicine
Subjects:
IgG glycosylation
Anti-spike IgG
SARS-CoV-2
COVID-19
Coronavirus
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422001414

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