Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients

Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients

PRINCIPLES: Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical outcome in NSCLC patients treated with platinum-...

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Bibliographic Details
Main Authors: F zhou, Z yu, T jiang, H lv, R yao, J liang
Format: Article
Language:English
Published: SMW supporting association (Trägerverein Swiss Medical Weekly SMW) 2011-10-01
Series:Swiss Medical Weekly
Subjects:
carcinoma
genetic polymorphisms
glutathione S-transferase pi
non-small-cell lung
platinum
X-ray repair cross complementing protein 1
Online Access:https://www.smw.ch/index.php/smw/article/view/1367

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