Emerging Role of Myeloperoxidase in the Prognosis of Nephrotic Syndrome Patients Before and After Steroid Therapy
Background: Myeloperoxidase (MPO) is a myelocyte derived iron containing enzyme particularly involved in host defense by destroying foreign micro organisms invading the body. Numerous evidences suggest that MPO is involved in the pathogenesis of many inflammatory diseases, especially atheroscler...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6222/12532_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: Myeloperoxidase (MPO) is a myelocyte derived
iron containing enzyme particularly involved in host defense by
destroying foreign micro organisms invading the body. Numerous
evidences suggest that MPO is involved in the pathogenesis of
many inflammatory diseases, especially atherosclerosis.
Aim: Present study deals with the role of MPO in the renal function
and progression of disease in Nephrotic syndrome patients.
Study Design and Settings: Case- Control Study carried out in
Kasturba Medical College Hospital, Mangalore, India.
Materials and Methods: Forty newly diagnosed Nephrotic
syndrome cases, 40 age and sex matched healthy controls and
15 subjects in Nephrotic syndrome remission, were included in
the study. Myeloperoxidase enzyme was assayed by 4 amino
antipyrine methods in all the subjects. Other renal parameters like
urea, creatinine, Blood Urea Nitrogen (BUN), BUN- Creatinine ratio
(BUN/Cr) total protein, albumin, globulin, albumin – globulin ratio
(A/G ratio) and estimated Glomerular Filtration Rate (eGFR) were
also analysed. 24 hour urine protein-creatinine ratio was estimated
in Nephrotic syndrome cases and remission group by turbidimetric
assay.
Statistical Analysis: Students paired t-test and Wilcoxon Signed
Rank test were used for the comparison of the data. Pearson and
Spearman analyses were used for correlation of the parameters.
Results: MPO levels were found to be high in Nephrotic syndrome
cases when compared to healthy controls. Urea, creatinine,
BUN, BUN/Cr ratio and eGFR were high in Nephrotic syndrome
cases while total protein, albumin, globulin and A/G ratio showed
decreased levels. MPO had a positive correlation with creatinine
and urine protein-creatinine ratio in Nephrotic syndrome. During
remission, MPO levels decreased significantly while total protein
and albumin levels increased.
Conclusion: Myeloperoxidase enzyme is found to be elevated
and it strongly correlated with the severity of disease in Nephrotic
syndrome. Further studies can be done to use MPO as a therapeutic
target in Nephrotic syndrome to ameliorate the symptoms. |
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| ISSN: | 2249-782X 0973-709X |