The RAGE signaling in osteoporosis
Osteoporosis (OP), characterized by an imbalance of bone remodeling between formation and resorption, has become a health issue worldwide. The receptor for advanced glycation end product (RAGE), a transmembrane protein in the immunoglobin family, has multiple ligands and has been involved in many ch...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222300834X |
| _version_ | 1797744159720734720 |
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| author | Jianguo Zhou Shiwei Liu Shengrong Bi Weihao Kong Rui Qian Xunlu Xie Ming Zeng Xiaowei Jiang Zhibin Liao Ming Shuai Wei Liu Long Cheng Moujian Wu |
| author_facet | Jianguo Zhou Shiwei Liu Shengrong Bi Weihao Kong Rui Qian Xunlu Xie Ming Zeng Xiaowei Jiang Zhibin Liao Ming Shuai Wei Liu Long Cheng Moujian Wu |
| author_sort | Jianguo Zhou |
| collection | DOAJ |
| description | Osteoporosis (OP), characterized by an imbalance of bone remodeling between formation and resorption, has become a health issue worldwide. The receptor for advanced glycation end product (RAGE), a transmembrane protein in the immunoglobin family, has multiple ligands and has been involved in many chronic diseases, such as diabetes and OP. Increasing evidence shows that activation of the RAGE signaling negatively affects bone remodeling. Ligands, such as advanced glycation end products (AGEs), S100, β-amyloid (Aβ), and high mobility group box 1 (HMGB1), have been well documented that they may negatively regulate the proliferation and differentiation of osteoblasts and positively stimulate osteoclastogenesis by activating the expression of RAGE. In this review, we comprehensively discuss the structure of RAGE and its biological functions in the pathogenesis of OP. The research findings suggest that RAGE signaling has become a potential target for the therapeutic management of OP. |
| first_indexed | 2024-03-12T15:05:45Z |
| format | Article |
| id | doaj.art-d1d69e46e26b4202ba2ff35a6378bf68 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:05:45Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-d1d69e46e26b4202ba2ff35a6378bf682023-08-13T04:52:23ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115044The RAGE signaling in osteoporosisJianguo Zhou0Shiwei Liu1Shengrong Bi2Weihao Kong3Rui Qian4Xunlu Xie5Ming Zeng6Xiaowei Jiang7Zhibin Liao8Ming Shuai9Wei Liu10Long Cheng11Moujian Wu12Department of Joint Surgery, Ganzhou People’s Hospital, Ganzhou 341000, China; Corresponding author.Department of Joint Surgery, Ganzhou People’s Hospital, Ganzhou 341000, ChinaDepartment of Joint Surgery, Ganzhou People’s Hospital, Ganzhou 341000, ChinaDepartment of Joint Surgery, Ganzhou People’s Hospital, Ganzhou 341000, ChinaDepartment of Joint Surgery, Ganzhou People’s Hospital, Ganzhou 341000, ChinaDepartment of Pathology, Ganzhou People’s Hospital, Ganzhou 341000, ChinaDepartment of Orthopedics, Ruijin Traditional Chinese Medicine Hospital, Ruijin 342500, ChinaDepartment of Joint Surgery, Ningdu County People's Hospital, Ningdu 342800, ChinaDepartment of Joint Surgery, Ningdu County People's Hospital, Ningdu 342800, ChinaDepartment of Orthopedics, Chongyi County People's Hospital, Chongyi 341300, ChinaDepartment of Orthopedics, Ningdu County Traditional Chinese Medicine Hospital, Ningdu 342800, ChinaDepartment of Orthopedics, Ningdu County Traditional Chinese Medicine Hospital, Ningdu 342800, ChinaDepartment of Orthopedics, Xingguo County Traditional Chinese Medicine Hospital, Xingguo 342400, ChinaOsteoporosis (OP), characterized by an imbalance of bone remodeling between formation and resorption, has become a health issue worldwide. The receptor for advanced glycation end product (RAGE), a transmembrane protein in the immunoglobin family, has multiple ligands and has been involved in many chronic diseases, such as diabetes and OP. Increasing evidence shows that activation of the RAGE signaling negatively affects bone remodeling. Ligands, such as advanced glycation end products (AGEs), S100, β-amyloid (Aβ), and high mobility group box 1 (HMGB1), have been well documented that they may negatively regulate the proliferation and differentiation of osteoblasts and positively stimulate osteoclastogenesis by activating the expression of RAGE. In this review, we comprehensively discuss the structure of RAGE and its biological functions in the pathogenesis of OP. The research findings suggest that RAGE signaling has become a potential target for the therapeutic management of OP.http://www.sciencedirect.com/science/article/pii/S075333222300834XOsteoporosisRAGEOsteoblastsOsteoclastogenesisAGEsS100 |
| spellingShingle | Jianguo Zhou Shiwei Liu Shengrong Bi Weihao Kong Rui Qian Xunlu Xie Ming Zeng Xiaowei Jiang Zhibin Liao Ming Shuai Wei Liu Long Cheng Moujian Wu The RAGE signaling in osteoporosis Biomedicine & Pharmacotherapy Osteoporosis RAGE Osteoblasts Osteoclastogenesis AGEs S100 |
| title | The RAGE signaling in osteoporosis |
| title_full | The RAGE signaling in osteoporosis |
| title_fullStr | The RAGE signaling in osteoporosis |
| title_full_unstemmed | The RAGE signaling in osteoporosis |
| title_short | The RAGE signaling in osteoporosis |
| title_sort | rage signaling in osteoporosis |
| topic | Osteoporosis RAGE Osteoblasts Osteoclastogenesis AGEs S100 |
| url | http://www.sciencedirect.com/science/article/pii/S075333222300834X |
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