Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea
This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control, anti-LOX, VD (negative pressure value of −300...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Asian Journal of Andrology |
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| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=5;spage=485;epage=492;aulast= |
| _version_ | 1818259037071867904 |
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| author | Tao Li Fu-Dong Fu Chang-Jing Wu Feng Qin Run Wang Jiu-Hong Yuan |
| author_facet | Tao Li Fu-Dong Fu Chang-Jing Wu Feng Qin Run Wang Jiu-Hong Yuan |
| author_sort | Tao Li |
| collection | DOAJ |
| description | This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control, anti-LOX, VD (negative pressure value of −300 mmHg), and anti-LOX + VD. Penile length was measured by a modified VD method and verified on exposed length data. Intracavernous pressure (ICP) and maximum ICP/mean arterial pressure (MAP) ratio were recorded to assess erectile function. For corpus cavernosum, LOX activity and concentrations of pyridinoline, desmosine, hydroxyproline, and elastin were analyzed; transmission electron microscope and Hart's elastin staining were performed to monitor microstructural changes. Anti-LOX and VD significantly lengthened the penis by 10.8% (3.75 mm) and 8.2% (2.48 mm) compared with the control group, respectively, while anti-LOX + VD achieved the longest penile size (40.58 ± 0.40 mm) which was 17.4% longer than the control group (34.58 ± 0.54 mm). After 1-week washout, no penile retraction was observed. Meanwhile, exposed penile length data confirmed that the penis in the anti-LOX + VD group was also significantly longer. Anti-LOX inhibited LOX activity to reduce pyridinoline level, which led the penile tunica albuginea remodeling. However, it had no effect on hydroxyproline, desmosine, and elastin levels. Moreover, anti-LOX had no impact on erectile function, which was determined by ICP and ICP/MAP ratio. These results suggest that anti-LOX elongates the penis by reducing pyridinoline, which induces tunica albuginea remodeling. This lengthening effect was more obvious when combined with a VD. All procedures had no impact on erectile function. |
| first_indexed | 2024-12-12T18:09:04Z |
| format | Article |
| id | doaj.art-d1d6efa2c153423889cc964b7eaa3fb0 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-12T18:09:04Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-d1d6efa2c153423889cc964b7eaa3fb02022-12-22T00:16:25ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622020-01-0122548549210.4103/aja.aja_120_19Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albugineaTao LiFu-Dong FuChang-Jing WuFeng QinRun WangJiu-Hong YuanThis study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control, anti-LOX, VD (negative pressure value of −300 mmHg), and anti-LOX + VD. Penile length was measured by a modified VD method and verified on exposed length data. Intracavernous pressure (ICP) and maximum ICP/mean arterial pressure (MAP) ratio were recorded to assess erectile function. For corpus cavernosum, LOX activity and concentrations of pyridinoline, desmosine, hydroxyproline, and elastin were analyzed; transmission electron microscope and Hart's elastin staining were performed to monitor microstructural changes. Anti-LOX and VD significantly lengthened the penis by 10.8% (3.75 mm) and 8.2% (2.48 mm) compared with the control group, respectively, while anti-LOX + VD achieved the longest penile size (40.58 ± 0.40 mm) which was 17.4% longer than the control group (34.58 ± 0.54 mm). After 1-week washout, no penile retraction was observed. Meanwhile, exposed penile length data confirmed that the penis in the anti-LOX + VD group was also significantly longer. Anti-LOX inhibited LOX activity to reduce pyridinoline level, which led the penile tunica albuginea remodeling. However, it had no effect on hydroxyproline, desmosine, and elastin levels. Moreover, anti-LOX had no impact on erectile function, which was determined by ICP and ICP/MAP ratio. These results suggest that anti-LOX elongates the penis by reducing pyridinoline, which induces tunica albuginea remodeling. This lengthening effect was more obvious when combined with a VD. All procedures had no impact on erectile function.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=5;spage=485;epage=492;aulast=anti-lysyl oxidase; crosslinking; penile lengthening; tunica albuginea remodeling; vacuum device |
| spellingShingle | Tao Li Fu-Dong Fu Chang-Jing Wu Feng Qin Run Wang Jiu-Hong Yuan Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea Asian Journal of Andrology anti-lysyl oxidase; crosslinking; penile lengthening; tunica albuginea remodeling; vacuum device |
| title | Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea |
| title_full | Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea |
| title_fullStr | Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea |
| title_full_unstemmed | Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea |
| title_short | Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea |
| title_sort | anti lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea |
| topic | anti-lysyl oxidase; crosslinking; penile lengthening; tunica albuginea remodeling; vacuum device |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2020;volume=22;issue=5;spage=485;epage=492;aulast= |
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