An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

Malignant peripheral nerve sheath tumors (MPNST) are rare soft tissue sarcomas that are a major source of mortality in neurofibromatosis type 1 (NF1) patients. To identify MPNST driver genes, we performed a lentiviral short hairpin (sh) RNA screen, targeting all 130 genes up-regulated in neurofibrom...

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Bibliographic Details
Main Authors: Ami V. Patel, Katherine E. Chaney, Kwangmin Choi, David A. Largaespada, Ashish R. Kumar, Nancy Ratner
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:EBioMedicine
Subjects:
MPNST
MEIS1
ID1
RNAi
p27Kip
G0/G1 arrest
Sarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302511

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