Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain
The brain displays a remarkable ability to adapt following injury by altering its connections through neural plasticity. Many of the biological mechanisms that underlie plasticity are known, but there is little knowledge as to when, or where in the brain plasticity will occur following injury. This...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/34354 |
| _version_ | 1811181121524727808 |
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| author | Sean Froudist-Walsh Philip GF Browning James J Young Kathy L Murphy Rogier B Mars Lazar Fleysher Paula L Croxson |
| author_facet | Sean Froudist-Walsh Philip GF Browning James J Young Kathy L Murphy Rogier B Mars Lazar Fleysher Paula L Croxson |
| author_sort | Sean Froudist-Walsh |
| collection | DOAJ |
| description | The brain displays a remarkable ability to adapt following injury by altering its connections through neural plasticity. Many of the biological mechanisms that underlie plasticity are known, but there is little knowledge as to when, or where in the brain plasticity will occur following injury. This knowledge could guide plasticity-promoting interventions and create a more accurate roadmap of the recovery process following injury. We causally investigated the time-course of plasticity after hippocampal lesions using multi-modal MRI in monkeys. We show that post-injury plasticity is highly dynamic, but also largely predictable on the basis of the functional connectivity of the lesioned region, gradients of cell densities across the cortex and the pre-lesion network structure of the brain. The ability to predict which brain areas will plastically adapt their functional connectivity following injury may allow us to decipher why some brain lesions lead to permanent loss of cognitive function, while others do not. |
| first_indexed | 2024-04-11T09:14:19Z |
| format | Article |
| id | doaj.art-d1d804515d8242c7958aadae52bdac08 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:14:19Z |
| publishDate | 2018-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d1d804515d8242c7958aadae52bdac082022-12-22T04:32:25ZengeLife Sciences Publications LtdeLife2050-084X2018-11-01710.7554/eLife.34354Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brainSean Froudist-Walsh0https://orcid.org/0000-0003-4070-067XPhilip GF Browning1James J Young2https://orcid.org/0000-0001-9349-7519Kathy L Murphy3Rogier B Mars4https://orcid.org/0000-0001-6302-8631Lazar Fleysher5Paula L Croxson6https://orcid.org/0000-0002-4649-980XDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United StatesDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States; Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, United StatesDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United StatesComparative Biology Centre, Medical School, Newcastle University, United KingdomCentre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The NetherlandsDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, United StatesDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, United States; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United StatesThe brain displays a remarkable ability to adapt following injury by altering its connections through neural plasticity. Many of the biological mechanisms that underlie plasticity are known, but there is little knowledge as to when, or where in the brain plasticity will occur following injury. This knowledge could guide plasticity-promoting interventions and create a more accurate roadmap of the recovery process following injury. We causally investigated the time-course of plasticity after hippocampal lesions using multi-modal MRI in monkeys. We show that post-injury plasticity is highly dynamic, but also largely predictable on the basis of the functional connectivity of the lesioned region, gradients of cell densities across the cortex and the pre-lesion network structure of the brain. The ability to predict which brain areas will plastically adapt their functional connectivity following injury may allow us to decipher why some brain lesions lead to permanent loss of cognitive function, while others do not.https://elifesciences.org/articles/34354non-human primatesplasticitymultimodal MRIneurotoxic lesionshippocampusnetwork analysis |
| spellingShingle | Sean Froudist-Walsh Philip GF Browning James J Young Kathy L Murphy Rogier B Mars Lazar Fleysher Paula L Croxson Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain eLife non-human primates plasticity multimodal MRI neurotoxic lesions hippocampus network analysis |
| title | Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain |
| title_full | Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain |
| title_fullStr | Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain |
| title_full_unstemmed | Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain |
| title_short | Macro-connectomics and microstructure predict dynamic plasticity patterns in the non-human primate brain |
| title_sort | macro connectomics and microstructure predict dynamic plasticity patterns in the non human primate brain |
| topic | non-human primates plasticity multimodal MRI neurotoxic lesions hippocampus network analysis |
| url | https://elifesciences.org/articles/34354 |
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