Rate of speech decline in individuals with amyotrophic lateral sclerosis
Abstract Although speech declines rapidly in some individuals with amyotrophic lateral sclerosis (ALS), longitudinal changes in speech have rarely been characterized. The study objectives were to model the rate of decline in speaking rate and speech intelligibility as a function of disease onset sit...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-19651-1 |
| _version_ | 1798001570889072640 |
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| author | Marziye Eshghi Yana Yunusova Kathryn P. Connaghan Bridget J. Perry Marc F. Maffei James D. Berry Lorne Zinman Sanjay Kalra Lawrence Korngut Angela Genge Annie Dionne Jordan R. Green |
| author_facet | Marziye Eshghi Yana Yunusova Kathryn P. Connaghan Bridget J. Perry Marc F. Maffei James D. Berry Lorne Zinman Sanjay Kalra Lawrence Korngut Angela Genge Annie Dionne Jordan R. Green |
| author_sort | Marziye Eshghi |
| collection | DOAJ |
| description | Abstract Although speech declines rapidly in some individuals with amyotrophic lateral sclerosis (ALS), longitudinal changes in speech have rarely been characterized. The study objectives were to model the rate of decline in speaking rate and speech intelligibility as a function of disease onset site, sex, and age at onset in 166 individuals with ALS; and estimate time to speech loss from symptom onset. We also examined the association between clinical (speaking rate/intelligibility) measures and patient-reported measures of ALS progression (ALSFRS-R). Speech measures declined faster in the bulbar-onset group than in the spinal-onset group. The rate of decline was not significantly affected by sex and age. Functional speech was still maintained at 60 months since disease onset for most patients with spinal onset. However, the time to speech loss was 23 months based on speaking rate < 120 (w/m) and 32 months based on speech intelligibility < 85% in individuals with ALS-bulbar onset. Speech measures were more responsive to functional decline than were the patient-reported measures. The findings of this study will inform future work directed toward improving speech prognosis in ALS, which is critical for determining the appropriate timing of interventions, providing appropriate counseling for patients, and evaluating functional changes during clinical trials. |
| first_indexed | 2024-04-11T11:38:22Z |
| format | Article |
| id | doaj.art-d1d83f13de6d4055a49c73802aecdbd7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T11:38:22Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d1d83f13de6d4055a49c73802aecdbd72022-12-22T04:25:53ZengNature PortfolioScientific Reports2045-23222022-09-0112111310.1038/s41598-022-19651-1Rate of speech decline in individuals with amyotrophic lateral sclerosisMarziye Eshghi0Yana Yunusova1Kathryn P. Connaghan2Bridget J. Perry3Marc F. Maffei4James D. Berry5Lorne Zinman6Sanjay Kalra7Lawrence Korngut8Angela Genge9Annie Dionne10Jordan R. Green11Depatment of Communication Sciences and Disorders, MGH Institute of Health ProfessionsDepartment of Speech-Language Pathology, Rehabilitation Sciences Institute, University of TorontoDepatment of Communication Sciences and Disorders, MGH Institute of Health ProfessionsDepatment of Communication Sciences and Disorders, MGH Institute of Health ProfessionsDepatment of Communication Sciences and Disorders, MGH Institute of Health ProfessionsDepartment of Neurology, Sean M. Healey and AMG Center for ALS, MGHDivision of Neurology, Department of Medicine, University of TorontoNeuroscience and Mental Health Institute, University of AlbertaDepartment of Clinical Neurosciences, Hotchkiss Brain Institute, University of CalgaryDepartment of Neurology and Neurosurgery, Clinical Research Unit, Montreal Neurological Institute & HospitalCentre de Recherche du CHU de Québec - Université LavalDepatment of Communication Sciences and Disorders, MGH Institute of Health ProfessionsAbstract Although speech declines rapidly in some individuals with amyotrophic lateral sclerosis (ALS), longitudinal changes in speech have rarely been characterized. The study objectives were to model the rate of decline in speaking rate and speech intelligibility as a function of disease onset site, sex, and age at onset in 166 individuals with ALS; and estimate time to speech loss from symptom onset. We also examined the association between clinical (speaking rate/intelligibility) measures and patient-reported measures of ALS progression (ALSFRS-R). Speech measures declined faster in the bulbar-onset group than in the spinal-onset group. The rate of decline was not significantly affected by sex and age. Functional speech was still maintained at 60 months since disease onset for most patients with spinal onset. However, the time to speech loss was 23 months based on speaking rate < 120 (w/m) and 32 months based on speech intelligibility < 85% in individuals with ALS-bulbar onset. Speech measures were more responsive to functional decline than were the patient-reported measures. The findings of this study will inform future work directed toward improving speech prognosis in ALS, which is critical for determining the appropriate timing of interventions, providing appropriate counseling for patients, and evaluating functional changes during clinical trials.https://doi.org/10.1038/s41598-022-19651-1 |
| spellingShingle | Marziye Eshghi Yana Yunusova Kathryn P. Connaghan Bridget J. Perry Marc F. Maffei James D. Berry Lorne Zinman Sanjay Kalra Lawrence Korngut Angela Genge Annie Dionne Jordan R. Green Rate of speech decline in individuals with amyotrophic lateral sclerosis Scientific Reports |
| title | Rate of speech decline in individuals with amyotrophic lateral sclerosis |
| title_full | Rate of speech decline in individuals with amyotrophic lateral sclerosis |
| title_fullStr | Rate of speech decline in individuals with amyotrophic lateral sclerosis |
| title_full_unstemmed | Rate of speech decline in individuals with amyotrophic lateral sclerosis |
| title_short | Rate of speech decline in individuals with amyotrophic lateral sclerosis |
| title_sort | rate of speech decline in individuals with amyotrophic lateral sclerosis |
| url | https://doi.org/10.1038/s41598-022-19651-1 |
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