Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.

Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.

Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly from knockout mice, has suggested that ITK plays a particularly important function in Th2 cells and this has prompted significant efforts to dis...

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Bibliographische Detailangaben
Hauptverfasser: Angela Deakin, Graham Duddy, Steve Wilson, Steve Harrison, Judi Latcham, Mick Fulleylove, Sylvia Fung, Jason Smith, Mike Pedrick, Tom McKevitt, Leigh Felton, Joanne Morley, Diana Quint, Dilniya Fattah, Brian Hayes, Jade Gough, Roberto Solari
Format: Artikel
Sprache:English
Veröffentlicht: Public Library of Science (PLoS) 2014-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC4174519?pdf=render

Online

http://europepmc.org/articles/PMC4174519?pdf=render

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