Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p>Targeted therapies may impact the natural history of bladder cancer based upon their pharmacokinetics. The Her2/<it>neu</it> receptor tyrosine kinase, overexpressed by half of all primary urothelial carcinomas, has rece...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-09-01
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| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/3/1/9110 |
| _version_ | 1818262914461597696 |
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| author | Goodman Oscar B Milowsky Matthew I Kaplan Jodi Hussain Maha Nanus David M |
| author_facet | Goodman Oscar B Milowsky Matthew I Kaplan Jodi Hussain Maha Nanus David M |
| author_sort | Goodman Oscar B |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Introduction</p> <p>Targeted therapies may impact the natural history of bladder cancer based upon their pharmacokinetics. The Her2/<it>neu</it> receptor tyrosine kinase, overexpressed by half of all primary urothelial carcinomas, has recently been examined as a therapeutic target in bladder cancer in a prospective phase II multicenter trial (NCI-198) that enrolled 109 patients with advanced bladder carcinomas for treatment with trastuzumab in combination with paclitaxel, carboplatin, and gemcitabine. We report on documented isolated Her2/<it>neu</it> positive carcinomatous meningitis in a patient treated with trastuzumab.</p> <p>Case presentation</p> <p>A 61-year-old Caucasian man with metastatic bladder cancer was treated with neoadjuvant chemotherapy in combination with trastuzumab with a partial response that was followed by a complete response after surgery. He relapsed with isolated Her2/<it>neu</it> positive carcinomatous meningitis.</p> <p>Conclusion</p> <p>Carcinomatous meningitis in bladder cancer is extremely rare. This is the first case reported of Her2/<it>neu</it> positive carcinomatous meningitis. Disease recurred solely at a sanctuary site, demonstrating that despite the systemic efficacy of trastuzumab in combination with chemotherapy, its inability to enter the central nervous system potentially contributes to the unusual site of disease recurrence.</p> |
| first_indexed | 2024-12-12T19:10:41Z |
| format | Article |
| id | doaj.art-d1da209b1c2d4142b9a5ec349676b3d2 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-12T19:10:41Z |
| publishDate | 2009-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-d1da209b1c2d4142b9a5ec349676b3d22022-12-22T00:14:51ZengBMCJournal of Medical Case Reports1752-19472009-09-0131911010.4076/1752-1947-3-9110Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literatureGoodman Oscar BMilowsky Matthew IKaplan JodiHussain MahaNanus David M<p>Abstract</p> <p>Introduction</p> <p>Targeted therapies may impact the natural history of bladder cancer based upon their pharmacokinetics. The Her2/<it>neu</it> receptor tyrosine kinase, overexpressed by half of all primary urothelial carcinomas, has recently been examined as a therapeutic target in bladder cancer in a prospective phase II multicenter trial (NCI-198) that enrolled 109 patients with advanced bladder carcinomas for treatment with trastuzumab in combination with paclitaxel, carboplatin, and gemcitabine. We report on documented isolated Her2/<it>neu</it> positive carcinomatous meningitis in a patient treated with trastuzumab.</p> <p>Case presentation</p> <p>A 61-year-old Caucasian man with metastatic bladder cancer was treated with neoadjuvant chemotherapy in combination with trastuzumab with a partial response that was followed by a complete response after surgery. He relapsed with isolated Her2/<it>neu</it> positive carcinomatous meningitis.</p> <p>Conclusion</p> <p>Carcinomatous meningitis in bladder cancer is extremely rare. This is the first case reported of Her2/<it>neu</it> positive carcinomatous meningitis. Disease recurred solely at a sanctuary site, demonstrating that despite the systemic efficacy of trastuzumab in combination with chemotherapy, its inability to enter the central nervous system potentially contributes to the unusual site of disease recurrence.</p>http://www.jmedicalcasereports.com/content/3/1/9110 |
| spellingShingle | Goodman Oscar B Milowsky Matthew I Kaplan Jodi Hussain Maha Nanus David M Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature Journal of Medical Case Reports |
| title | Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature |
| title_full | Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature |
| title_fullStr | Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature |
| title_full_unstemmed | Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature |
| title_short | Carcinomatous meningitis in a patient with Her2/<it>neu</it> expressing bladder cancer following trastuzumab and chemotherapy: a case report and review of the literature |
| title_sort | carcinomatous meningitis in a patient with her2 it neu it expressing bladder cancer following trastuzumab and chemotherapy a case report and review of the literature |
| url | http://www.jmedicalcasereports.com/content/3/1/9110 |
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