Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection
Dai Sonoda,1,2 Yosuke Matsuura,1 Junji Ichinose,1 Masayuki Nakao,1 Hironori Ninomiya,3 Mingyon Mun,1 Yuichi Ishikawa,3 Ken Nakagawa,1 Yukitoshi Satoh,2 Sakae Okumura11Department of Thoracic Surgical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-07-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/ultra-late-recurrence-of-non-small-cell-lung-cancer-over-10-years-afte-peer-reviewed-article-CMAR |
| _version_ | 1818029439528730624 |
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| author | Sonoda D Matsuura Y Ichinose J Nakao M Ninomiya H Mun M Ishikawa Y Nakagawa K Satoh Y Okumura S |
| author_facet | Sonoda D Matsuura Y Ichinose J Nakao M Ninomiya H Mun M Ishikawa Y Nakagawa K Satoh Y Okumura S |
| author_sort | Sonoda D |
| collection | DOAJ |
| description | Dai Sonoda,1,2 Yosuke Matsuura,1 Junji Ichinose,1 Masayuki Nakao,1 Hironori Ninomiya,3 Mingyon Mun,1 Yuichi Ishikawa,3 Ken Nakagawa,1 Yukitoshi Satoh,2 Sakae Okumura11Department of Thoracic Surgical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan; 2Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; 3Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, JapanPurpose: Most postoperative recurrences of non-small cell lung cancer (NSCLC) develop within 5 years after curative resection, with ultra-late recurrences developing over 10 years after the resection being rare. This study aimed to analyze the features of ultra-late recurrence in cases with NSCLC who had undergone curative resection.Patients and methods: Among 1458 consecutive cases with NSCLC who underwent curative resection with systematic lymph node dissection during 1990–2006, 12 cases developed recurrence over 10 years after the resection. We defined the recurrence developing over 10 years after the resection as ultra-late recurrence and analyzed the factors related to it.Results: Among the 1458 cases, recurrence developed in 476 (32.6%) cases. Of them, ultra-late recurrence developed in 12 (2.5%) cases. The ultra-late recurrence was histopathologically classified as adenocarcinoma in 11 cases and atypical carcinoid in 1 case. All cases were of invasive carcinoma. We compared ultra-late recurrence cases with non-recurrence cases and showed that none of the examined factors significantly influenced ultra-late recurrence; however, lymphatic invasion was close to significantly influencing it. There were two cases in which recurrence developed over 15 years after the resection; both cases were of adenocarcinoma with anaplastic lymphoma kinase (ALK) rearrangement.Conclusion: There is a possibility of ultra-late recurrence developing over 10 years after the resection of any invasive NSCLC. Lymphatic invasion is close to significantly influencing ultra-late recurrence. Furthermore, a long follow-up period may be required in cases with adenocarcinoma with ALK rearrangement because it has the possibility of recurrence over 15 years after the resection.Keywords: lung cancer, recurrence, resection, ALK rearrangement |
| first_indexed | 2024-12-10T05:19:42Z |
| format | Article |
| id | doaj.art-d1dc3b799d904528b1703555cbe98478 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-10T05:19:42Z |
| publishDate | 2019-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-d1dc3b799d904528b1703555cbe984782022-12-22T02:00:50ZengDove Medical PressCancer Management and Research1179-13222019-07-01Volume 116765677447261Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resectionSonoda DMatsuura YIchinose JNakao MNinomiya HMun MIshikawa YNakagawa KSatoh YOkumura SDai Sonoda,1,2 Yosuke Matsuura,1 Junji Ichinose,1 Masayuki Nakao,1 Hironori Ninomiya,3 Mingyon Mun,1 Yuichi Ishikawa,3 Ken Nakagawa,1 Yukitoshi Satoh,2 Sakae Okumura11Department of Thoracic Surgical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan; 2Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; 3Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, JapanPurpose: Most postoperative recurrences of non-small cell lung cancer (NSCLC) develop within 5 years after curative resection, with ultra-late recurrences developing over 10 years after the resection being rare. This study aimed to analyze the features of ultra-late recurrence in cases with NSCLC who had undergone curative resection.Patients and methods: Among 1458 consecutive cases with NSCLC who underwent curative resection with systematic lymph node dissection during 1990–2006, 12 cases developed recurrence over 10 years after the resection. We defined the recurrence developing over 10 years after the resection as ultra-late recurrence and analyzed the factors related to it.Results: Among the 1458 cases, recurrence developed in 476 (32.6%) cases. Of them, ultra-late recurrence developed in 12 (2.5%) cases. The ultra-late recurrence was histopathologically classified as adenocarcinoma in 11 cases and atypical carcinoid in 1 case. All cases were of invasive carcinoma. We compared ultra-late recurrence cases with non-recurrence cases and showed that none of the examined factors significantly influenced ultra-late recurrence; however, lymphatic invasion was close to significantly influencing it. There were two cases in which recurrence developed over 15 years after the resection; both cases were of adenocarcinoma with anaplastic lymphoma kinase (ALK) rearrangement.Conclusion: There is a possibility of ultra-late recurrence developing over 10 years after the resection of any invasive NSCLC. Lymphatic invasion is close to significantly influencing ultra-late recurrence. Furthermore, a long follow-up period may be required in cases with adenocarcinoma with ALK rearrangement because it has the possibility of recurrence over 15 years after the resection.Keywords: lung cancer, recurrence, resection, ALK rearrangementhttps://www.dovepress.com/ultra-late-recurrence-of-non-small-cell-lung-cancer-over-10-years-afte-peer-reviewed-article-CMARlung cancerrecurrenceresectionALK rearrangement |
| spellingShingle | Sonoda D Matsuura Y Ichinose J Nakao M Ninomiya H Mun M Ishikawa Y Nakagawa K Satoh Y Okumura S Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection Cancer Management and Research lung cancer recurrence resection ALK rearrangement |
| title | Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection |
| title_full | Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection |
| title_fullStr | Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection |
| title_full_unstemmed | Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection |
| title_short | Ultra-late recurrence of non-small cell lung cancer over 10 years after curative resection |
| title_sort | ultra late recurrence of non small cell lung cancer over 10 years after curative resection |
| topic | lung cancer recurrence resection ALK rearrangement |
| url | https://www.dovepress.com/ultra-late-recurrence-of-non-small-cell-lung-cancer-over-10-years-afte-peer-reviewed-article-CMAR |
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